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Table 2 Immunostaining of HAS1, HAS3 and HAS2 in human ovary and its tumors

From: Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

 

HAS1 staining intensity*

HAS3 staining intensity*

HAS2 staining intensity

 

Stroma

Epithelium

Stroma

Epithelium

Stroma †

Epithelium ‡

      

weak

moderate

strong

Normal Ovary (n = 5)

0

0

0

0

37 (10 – 50%)

5

0

0

Benign (n = 10)

0

4 (1–5%)

0

4 (1–5%)

31 (10 – 50%)

0

5

5

Borderline (n = 4)

0

2 (5%)

0

1 (10%)

24 (10 – 25%)

1

2

1

Grade 1 + 2 (n = 10)

0

7 (5–50%)

0

6 (5–50%)

13 (10 – 25%)

3

4

3

Grade 3 (n = 10)

0

4 (1–10%)

0

7 (1–10%)

25 (10 – 50%)

6

4

0

  1. Benign = serous cystadenoma, Borderline = serous borderline tumor
  2. Grade 1–3 = serous epithelial cystadenocarcinoma
  3. * num. of positive samples (% of positive cells), † mean % of positive cells (range), ‡ distripution of staining intensity