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Table 2 Immunostaining of HAS1, HAS3 and HAS2 in human ovary and its tumors

From: Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

  HAS1 staining intensity* HAS3 staining intensity* HAS2 staining intensity
  Stroma Epithelium Stroma Epithelium Stroma † Epithelium ‡
       weak moderate strong
Normal Ovary (n = 5) 0 0 0 0 37 (10 – 50%) 5 0 0
Benign (n = 10) 0 4 (1–5%) 0 4 (1–5%) 31 (10 – 50%) 0 5 5
Borderline (n = 4) 0 2 (5%) 0 1 (10%) 24 (10 – 25%) 1 2 1
Grade 1 + 2 (n = 10) 0 7 (5–50%) 0 6 (5–50%) 13 (10 – 25%) 3 4 3
Grade 3 (n = 10) 0 4 (1–10%) 0 7 (1–10%) 25 (10 – 50%) 6 4 0
  1. Benign = serous cystadenoma, Borderline = serous borderline tumor
  2. Grade 1–3 = serous epithelial cystadenocarcinoma
  3. * num. of positive samples (% of positive cells), † mean % of positive cells (range), ‡ distripution of staining intensity
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BMC Cancer

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