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Table 2 Odds Ratios (95% CI) for head and neck cancer according to the studied polymorphisms

From: A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population

 

283 Cases

295 Controls

OR °

OR° for oral cavity (52 cases)

OR° for oropharynx (18 cases)

OR° for hypopharynx (23 cases)

OR° for larynx (186 cases)

 

N (%)

N (%)

(95% CI)

(95% CI)

(95% CI)

(95% CI)

(95% CI)

p53 intron 3

(rs1788332)

       

WW

191 (67.5)

209 (70.8)

1*

1*

1*

1*

1*

M carriers

92 (32.5)

86 (29.2)

1.30 (0.81 – 2.10)

1.46 (1.78 – 2.88)

1.75 (0.61 – 5.00)

0.55 (0.18 – 1.75)

1.17 (0.69 – 1.98)

p53exon4Arg72Pro

(rs1042522)

       

ArgArg

175 (61.85)

169 (57.3)

1*

1*

1*

1*

1*

Pro carriers

108 (38.2)

126 (42.7)

1.07 (0.68 – 1.67)

1.02 (0.53 – 1.97)

1.66 (0.59 – 4.62)

0.87 (0.34 – 2.22)

0.91 (0.55 – 1.49)

p53 intron 6

(rs1625895)

       

GG

194 (68.5)

192 (65.1)

1*

1*

1*

1*

1*

C carriers

89 (31.5)

86 (34.9)

0.99 (0.63 – 1.58)

0.49 (0.23 – 1.05)

1.28 (0.45 – 3.65)

0.70 (0.26 – 1.91)

1.00 (0.60 – 1.67)

p73 exon 2 G4A

(rs1801173/rs2273953)

       

GC/GC

187 (66.1)

214 (72.5)

1*

1*

1*

1*

1*

AT carriers

96 (33.9)

81 (27.5)

1.51 (0.94 – 2.43)

2.43 (1.23 – 4.81)§

1.99 (0.69 – 5.69)

0.48 (0.13 – 1.71)

1.46 (0.86 – 2.46)

  1. * Reference group
  2. ° OR adjusted for gender, alcohol, pack-years, physical activity and fruit and vegetables intake
  3. § This association (p-value = 0.01) didn't remain noteworthy after the FDR test correction because the statistically significant threshold was set at p-value = 0.0002.