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Table 2 Odds Ratios (95% CI) for head and neck cancer according to the studied polymorphisms

From: A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population

  283 Cases 295 Controls OR ° OR° for oral cavity (52 cases) OR° for oropharynx (18 cases) OR° for hypopharynx (23 cases) OR° for larynx (186 cases)
  N (%) N (%) (95% CI) (95% CI) (95% CI) (95% CI) (95% CI)
p53 intron 3
(rs1788332)
       
WW 191 (67.5) 209 (70.8) 1* 1* 1* 1* 1*
M carriers 92 (32.5) 86 (29.2) 1.30 (0.81 – 2.10) 1.46 (1.78 – 2.88) 1.75 (0.61 – 5.00) 0.55 (0.18 – 1.75) 1.17 (0.69 – 1.98)
p53exon4Arg72Pro
(rs1042522)
       
ArgArg 175 (61.85) 169 (57.3) 1* 1* 1* 1* 1*
Pro carriers 108 (38.2) 126 (42.7) 1.07 (0.68 – 1.67) 1.02 (0.53 – 1.97) 1.66 (0.59 – 4.62) 0.87 (0.34 – 2.22) 0.91 (0.55 – 1.49)
p53 intron 6
(rs1625895)
       
GG 194 (68.5) 192 (65.1) 1* 1* 1* 1* 1*
C carriers 89 (31.5) 86 (34.9) 0.99 (0.63 – 1.58) 0.49 (0.23 – 1.05) 1.28 (0.45 – 3.65) 0.70 (0.26 – 1.91) 1.00 (0.60 – 1.67)
p73 exon 2 G4A
(rs1801173/rs2273953)
       
GC/GC 187 (66.1) 214 (72.5) 1* 1* 1* 1* 1*
AT carriers 96 (33.9) 81 (27.5) 1.51 (0.94 – 2.43) 2.43 (1.23 – 4.81)§ 1.99 (0.69 – 5.69) 0.48 (0.13 – 1.71) 1.46 (0.86 – 2.46)
  1. * Reference group
  2. ° OR adjusted for gender, alcohol, pack-years, physical activity and fruit and vegetables intake
  3. § This association (p-value = 0.01) didn't remain noteworthy after the FDR test correction because the statistically significant threshold was set at p-value = 0.0002.