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Table 3 The risk evaluation of MDM2 SNP309 genotypes on the development of breast cancer in Taiwanese women

From: Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer

SNP309a

OR (95% CI)b

p-value

OR (95% CI)c

p-value

OR (95% CI)d

p-value

TT

1

 

1

 

1

 

TG

1.98 (1.00 to 3.98)

0.05

2.24 (0.97 to 5.19)

0.06

2.12 (0.90 to 5.00)

0.08

GG

2.26 (0.95 to 5.38)

0.07

3.40 (1.21 to 9.57)

0.02

3.05 (1.04 to 8.95)

0.04

TG+GG

2.06 (1.05 to 4.06)

0.04

2.48 (1.10 to 5.60)

0.03

2.30 (1.00 to 5.30)

0.05

  1. a The frequency of each genotype is referred to Table 2.
  2. b The crude OR values.
  3. c Age-adjusted OR values.
  4. d These OR values are the results adjusted for age, BMI, cardiovascular disease/diabetes, and OCP (Oral Contraceptive Pill) usage
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BMC Cancer

ISSN: 1471-2407

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