Table 1 Tumour xenotransplantations into 2 day old zebrafish
From: Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model
| Â | Tumour Transplants (grade and pTMN stage) | Number transplants (survivors) | Migration [presence of micro-metastases at 3 dpi] | total >5 [%] | Control Transplants | Number transplants (survivors) | Migration [presence of micro-metastases at 3 dpi] | total >5 [%] | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | <5 | 5 to 20 | >20 | Â | Â | Â | <5 | 5 to 20 | >20 | Â | Â |
1 | Pancreas G2; T3; N1 (13/14) R1, M1 | 80 (64) | 0 | 20 [4] | 25 [20] | 70.3% | Normal Pancreas | 80 (73) | 0 | 0 | 0 | 0 | 6.3 × 10-5 |
2 | Pancreas G2; pT3, pN1, pM1 | 60 (42) | 2 [0] | 18 [4] | 6 [4] | 57.1% | Chronic Pancreatitis | 60 (50) | 0 | 0 | 0 | 0 | 1.1 × 10-5 |
3 | Pancreas G2; pT1, pN1 (1/18) pM1 | 80 (46) | 0 | 18 [5] | 8 [7] | 56.5% | Chronic Pancreatitis | 80 (59) | 0 | 0 | 0 | 0 | 1.9 × 10-4 |
4 | Pancreas G3; pT3, pN1 mi (1/11) pM1 | 80 (65) | 0 | 24 [6] | 12 [9] | 55.4% | Chronic Pancreatitis | 80 (58) | 0 | 0 | 0 | 0 | 5.4 × 10-5 |
5 | Colon G2; pT3 pN1 (2/14) LN metas. | 80 (66) | 0 | 15 [7] | 14 [10] | 43.9% | Normal Tissue | 80 (72) | 0 | 0 | 0 | 0 | 0.9 × 10-6 |
6 | Stomach G2: pT3 pN2 (11/18 LK) | 80 (62) | 0 | 23 [6] | 11 [9] | 54.8% | Normal Tissue | 80 (68) | 0 | 0 | 0 | 0 | 2.9 × 10-5 |
7 | Stomach G2; ypT2b, ypN0 (0/20) | 80 (48) | 0 | 18 [5] | 7 [6] | 52.3% | Normal Tissue | 80 (51) | 0 | 0 | 0 | 0 | 1 × 10-6 |
| Â | Primary tumour cell injections | Number transplants (survivors) | Migration [presence of micro-metastases at 3 dpi] | total >5 [%] | Primary control cell injections | Number transplants (survivors) | Migration [presence of micro-metastases at 3 dpi] | total >5 [%] | p-value | ||||
| Â | Â | Â | <5 | 5 to 20 | >20 | Â | Â | Â | <5 | 5 to 20 | >20 | Â | Â |
1 | Pancreas | 80 (63) | 3 [0] | 38 [10] | 4 [4] | 66.6% | Normal Pancreas | 80 (69) | 0 | 0 | 0 | 0 | 9.1 × 10-5 |
2 | Pancreas | 80 (66) | 0 | 23 [7] | 3 [2] | 39.4% | Chronic Pancreatitis | 80 72 | 2 [0] | 0 | 0 | 0 | 7.6 × 10-5 |
3 | Pancreas | 80 (63) | 0 | 22 [7] | 6 [5] | 44.4% | Chronic Pancreatitis | 80 (61) | 1 [0] | 0 | 0 | 0 | 4 × 10-4 |
4 | Pancreas | 80 (63) | 0 | 23 [6] | 5 [4] | 44.4% | Chronic Pancreatitis | 80 (63) | 1 [0] | 0 | 0 | 0 | 5 × 10-4 |
5 | Colon | 80 (65) | 0 | 24 [7] | 5 [4] | 44.4 | Normal Tissue | 80 (59) | 1 | 0 | 0 | 0 | 2.7 × 10-5 |
6 | Stomach | 80 (68) | 0 | 24 [6] | 0 | 35.3 | Normal Tissue | 80 (69) | 0 | 0 | 0 | 0 | 6.8 × 10-6 |