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Table 4 Combined effects of genotype of related enzymes and energy-adjusted nutrient intakes in all breast cancer cases and controls in Brazilian women

From: Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women

Gene

Allele

Tertile 1 (lower)*

Tertile 2

Tertile 3

P trend

P interaction

  

Case/Control

OR†

(95%CI)†

Case/Control

OR

(95%CI)

Case/Control

OR

(95%CI)

  

Folate

            

MTHFR_AC

AA

72/105

1.00

-

87/89

1.40

(0.92–2.14)

110/85

1.76

(1.14–2.72)

0.003

0.024

 

AC+CC

68/47

1.95

(1.18–3.22)

55/64

1.31

(0.79–2.17)

66/68

1.45

(0.88–2.41)

0.109

 

MTHFR_CT

CC

73/60

1.00

-

62/75

0.72

(0.44–1.17)

90/87

0.84

(0.52–1.37)

0.417

0.043

 

CT+TT

67/92

0.60

(0.37–0.97)

80/78

0.86

(0.53–1.40)

86/66

1.08

(0.66–1.77)

0.011

 

MTR

AA

86/101

1.00

-

95/102

1.14

(0.75–1.72)

113/91

1.56

(1.01–2.43)

0.049

0.283

 

AG+GG

54/51

1.21

(0.73–2.00)

46/51

1.12

(0.66–1.90)

63/62

1.07

(0.65–1.77)

0.574

 

Vitamin B6

            

MTHFR_AC

AA

73/82

1.00

-

85/106

0.99

(0.63–1.55)

111/91

1.50

(0.95–2.37)

0.061

0.043

 

CA+CC

72/70

1.28

(0.79–2.06)

63/47

1.56

(0.92–2.63)

54/62

1.02

(0.61–1.72)

0.669

 

MTHFR_CT

CC

78/68

1.00

-

68/75

0.80

(0.48–1.33)

79/79

0.90

(0.55–1.48)

0.914

0.273

 

CT+TT

67/84

0.71

(0.43–1.16)

80/78

0.91

(0.56–1.46)

86/74

1.03

(0.64–1.67)

0.105

 

MTR

AA

91/95

1.00

-

98/100

1.04

(0.67–1.61)

105/99

1.18

(0.77–1.81)

0.435

1.000

 

AG+GG

54/57

0.92

(0.57–1.50)

50/53

0.95

(0.57–1.59)

59/54

1.07

(0.64–1.79)

0.538

 

Vitamin B12

            

MTHFR_AC

AA

96/94

1.00

-

76/96

0.78

(0.50–1.20)

97/89

1.10

(0.72–1.68)

0.662

0.088

 

CA+CC

69/58

1.23

(0.76–2.00)

67/57

1.22

(0.77–1.96)

53/64

0.79

(0.49–1.30)

0.167

 

MTHFR_CT

CC

83/70

1.00

-

79/70

0.90

(0.55–1.47)

63/82

0.59

(0.36–0.97)

0.073

0.022

 

CT+TT

82/82

0.76

(0.46–1.24)

64/83

0.62

(0.37–1.05)

87/71

1.00

(0.63–1.60)

0.349

 

MTR

AA

105/94

1.00

-

94/105

0.79

(0.52–1.20)

95/95

0.90

(0.59–1.38)

0.560

0.592

 

AG+GG

60/58

0.81

(0.51–1.31)

48/48

0.92

(0.54–1.57)

55/58

0.76

(0.47–1.23)

0.923

 
  1. *Energy-adjusted intakes were categorized among controls by tertiles of folate, vitamin B6, and vitamin B12, respectively.
  2. †Adjusted for smoking status (never/ever), alcohol consumption (never/ever), moderate physical activity in the preceding 5 years (no/yes), and number of live births (nulliparous/1–2/≥3).