Gene | Allele | Tertile 1 (lower)* | Tertile 2 | Tertile 3 | P trend | P interaction | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Case/Control | OR†| (95%CI)†| Case/Control | OR | (95%CI) | Case/Control | OR | (95%CI) |  |  |
Folate | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MTHFR_AC | AA | 72/105 | 1.00 | - | 87/89 | 1.40 | (0.92–2.14) | 110/85 | 1.76 | (1.14–2.72) | 0.003 | 0.024 |
 | AC+CC | 68/47 | 1.95 | (1.18–3.22) | 55/64 | 1.31 | (0.79–2.17) | 66/68 | 1.45 | (0.88–2.41) | 0.109 |  |
MTHFR_CT | CC | 73/60 | 1.00 | - | 62/75 | 0.72 | (0.44–1.17) | 90/87 | 0.84 | (0.52–1.37) | 0.417 | 0.043 |
 | CT+TT | 67/92 | 0.60 | (0.37–0.97) | 80/78 | 0.86 | (0.53–1.40) | 86/66 | 1.08 | (0.66–1.77) | 0.011 |  |
MTR | AA | 86/101 | 1.00 | - | 95/102 | 1.14 | (0.75–1.72) | 113/91 | 1.56 | (1.01–2.43) | 0.049 | 0.283 |
 | AG+GG | 54/51 | 1.21 | (0.73–2.00) | 46/51 | 1.12 | (0.66–1.90) | 63/62 | 1.07 | (0.65–1.77) | 0.574 |  |
Vitamin B6 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MTHFR_AC | AA | 73/82 | 1.00 | - | 85/106 | 0.99 | (0.63–1.55) | 111/91 | 1.50 | (0.95–2.37) | 0.061 | 0.043 |
 | CA+CC | 72/70 | 1.28 | (0.79–2.06) | 63/47 | 1.56 | (0.92–2.63) | 54/62 | 1.02 | (0.61–1.72) | 0.669 |  |
MTHFR_CT | CC | 78/68 | 1.00 | - | 68/75 | 0.80 | (0.48–1.33) | 79/79 | 0.90 | (0.55–1.48) | 0.914 | 0.273 |
 | CT+TT | 67/84 | 0.71 | (0.43–1.16) | 80/78 | 0.91 | (0.56–1.46) | 86/74 | 1.03 | (0.64–1.67) | 0.105 |  |
MTR | AA | 91/95 | 1.00 | - | 98/100 | 1.04 | (0.67–1.61) | 105/99 | 1.18 | (0.77–1.81) | 0.435 | 1.000 |
 | AG+GG | 54/57 | 0.92 | (0.57–1.50) | 50/53 | 0.95 | (0.57–1.59) | 59/54 | 1.07 | (0.64–1.79) | 0.538 |  |
Vitamin B12 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MTHFR_AC | AA | 96/94 | 1.00 | - | 76/96 | 0.78 | (0.50–1.20) | 97/89 | 1.10 | (0.72–1.68) | 0.662 | 0.088 |
 | CA+CC | 69/58 | 1.23 | (0.76–2.00) | 67/57 | 1.22 | (0.77–1.96) | 53/64 | 0.79 | (0.49–1.30) | 0.167 |  |
MTHFR_CT | CC | 83/70 | 1.00 | - | 79/70 | 0.90 | (0.55–1.47) | 63/82 | 0.59 | (0.36–0.97) | 0.073 | 0.022 |
 | CT+TT | 82/82 | 0.76 | (0.46–1.24) | 64/83 | 0.62 | (0.37–1.05) | 87/71 | 1.00 | (0.63–1.60) | 0.349 |  |
MTR | AA | 105/94 | 1.00 | - | 94/105 | 0.79 | (0.52–1.20) | 95/95 | 0.90 | (0.59–1.38) | 0.560 | 0.592 |
 | AG+GG | 60/58 | 0.81 | (0.51–1.31) | 48/48 | 0.92 | (0.54–1.57) | 55/58 | 0.76 | (0.47–1.23) | 0.923 |  |