Gene | Allele | Total | Premenopausal women | Postmenopausal women | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | Case/Control | OR†| (95% CI)†| Case/Control | OR‡ | (95% CI)‡ | Case/Control | OR‡ | (95% CI)‡ |
MTHFR_AC | AA | 269/279 | 1.00 | - | 117/107 | 1.00 | - | 152/172 | 1.00 | - |
 | AC | 168/157 | 1.11 | (0.83–1.50) | 63/52 | 1.09 | (0.68–1.75) | 105/105 | 1.11 | (0.77–1.58) |
 | CC | 21/22 | 1.03 | (0.51–2.10) | 4/10 | 0.39 | (0.11–1.35) | 17/12 | 1.96 | (0.88–4.37) |
 | P trend |  | 0.543 |  |  | 0.585 |  |  | 0.161 |  |
 | AC+CC | 189/179 | 1.11 | (0.83–1.48) | 67/62 | 0.99 | (0.63–1.55) | 122/117 | 1.18 | (0.84–1.67) |
MTHFR_CT | CC | 225/222 | 1.00 | - | 93/86 | 1.00 | - | 132/136 | 1.00 | - |
 | CT | 188/187 | 1.02 | (0.77–1.36) | 75/68 | 0.98 | (0.62–1.56) | 113/119 | 0.96 | (0.67–1.38) |
 | TT | 45/49 | 0.88 | (0.55–1.42) | 16/15 | 0.88 | (0.40–1.95) | 29/34 | 0.78 | (0.44–1.38) |
 | P trend |  | 0.743 |  |  | 0.789 |  |  | 0.515 |  |
 | CT+TT | 233/236 | 0.99 | (0.76–1.30) | 91/83 | 0.96 | (0.62–1.49) | 142/153 | 0.92 | (0.65–1.30) |
MTR | AA | 294/294 | 1.00 | - | 118/105 | 1.00 | - | 176/189 | 1.00 | - |
 | AG | 135/149 | 0.81 | (0.59–1.10) | 53/56 | 0.76 | (0.47–1.23) | 82/93 | 0.93 | (0.64–1.35) |
 | GG | 28/15 | 1.99 | (1.01–3.92) | 13/8 | 1.34 | (0.51–3.51) | 15/7 | 2.28 | (0.88–5.90) |
 | P trend |  | 0.801 |  |  | 0.738 |  |  | 0.543 |  |
 | AG+GG | 163/164 | 0.92 | (0.68–1.23) | 66/64 | 0.83 | (0.53–1.31) | 97/100 | 1.02 | (0.71–1.46) |