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Table 3 Association between genotype of related enzymes and breast cancer risk in Brazilian women

From: Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women

Gene

Allele

Total

Premenopausal women

Postmenopausal women

  

Case/Control

OR†

(95% CI)†

Case/Control

OR‡

(95% CI)‡

Case/Control

OR‡

(95% CI)‡

MTHFR_AC

AA

269/279

1.00

-

117/107

1.00

-

152/172

1.00

-

 

AC

168/157

1.11

(0.83–1.50)

63/52

1.09

(0.68–1.75)

105/105

1.11

(0.77–1.58)

 

CC

21/22

1.03

(0.51–2.10)

4/10

0.39

(0.11–1.35)

17/12

1.96

(0.88–4.37)

 

P trend

 

0.543

  

0.585

  

0.161

 
 

AC+CC

189/179

1.11

(0.83–1.48)

67/62

0.99

(0.63–1.55)

122/117

1.18

(0.84–1.67)

MTHFR_CT

CC

225/222

1.00

-

93/86

1.00

-

132/136

1.00

-

 

CT

188/187

1.02

(0.77–1.36)

75/68

0.98

(0.62–1.56)

113/119

0.96

(0.67–1.38)

 

TT

45/49

0.88

(0.55–1.42)

16/15

0.88

(0.40–1.95)

29/34

0.78

(0.44–1.38)

 

P trend

 

0.743

  

0.789

  

0.515

 
 

CT+TT

233/236

0.99

(0.76–1.30)

91/83

0.96

(0.62–1.49)

142/153

0.92

(0.65–1.30)

MTR

AA

294/294

1.00

-

118/105

1.00

-

176/189

1.00

-

 

AG

135/149

0.81

(0.59–1.10)

53/56

0.76

(0.47–1.23)

82/93

0.93

(0.64–1.35)

 

GG

28/15

1.99

(1.01–3.92)

13/8

1.34

(0.51–3.51)

15/7

2.28

(0.88–5.90)

 

P trend

 

0.801

  

0.738

  

0.543

 
 

AG+GG

163/164

0.92

(0.68–1.23)

66/64

0.83

(0.53–1.31)

97/100

1.02

(0.71–1.46)

  1. †Adjusted for smoking status (never/ever), alcohol consumption (never/ever), moderate physical activity in the preceding 5 years (no/yes), and number of live births (nulliparous/1–2/≥3).
  2. ‡Adjusted for age group (20-/30-/40-/50-/60-/≥70), ethnicity (white/mixed/black/yellow), smoking status (never/ever), alcohol consumption (never/ever), moderate physical activity in the preceding 5 years (no/yes), and number of live births (nulliparous/1–2/≥3).