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Table 8 Associations between PON1 Q192R and L55M genotypes and breast cancer

From: CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

PON1 Q192R QQ QR RR QR and RR
   Premenopausal     
Controls, n (%) 144 (62.6) 64 (27.8) 22 (9.6) 86 (37.4)
Cases by stage     
Local, n (%) 70 (63.6) 30 (27.3) 10 (9.1) 40 (36.4)
OR (95% CI)a 1.0 0.96 (0.55–1.60) 0.94 (0.32–2.17)b 0.95 (0.60–1.62)
Advanced, n (%) 65 (84.4) 11 (14.3) 1 (1.3) 12 (15.6)
OR (95% CI)a 1.0 0.42 (0.23–0.86) 0.23 (0.06–0.85)c 0.33 (0.14–0.60)
   Postmenopausal     
Controls, n (%) 196 (62.4) 88 (28.0) 30 (9.6) 118 (37.6)
Cases by stage     
Local, n (%) 221 (96.9) 6 (2.6) 1 (0.50) 7 (3.1)
OR (95% CI)a 1.0 0.06 (0.01–0.12) 0.04 (0.00–0.23)d 0.05 (0.00–0.10)
Advanced, n (%) 128 (96.9) 3 (2.3) 1 (0.8) 4 (3.1)
OR (95% CI)a 1.0 0.04 (0.01–0.16) 0.02 (0.00–0.25)e 0.05 (0.01–0.11)
PON1 L55M LL LM MM LM and MM
   Premenopausal     
Controls, n (%) 78 (33.9) 70 (30.4) 82 (35.7) 152 (66.1)
Cases by stage     
Local, n (%) 16 (14.6) 25 (22.7) 69 (62.7) 94 (85.4)
OR (95% CI)a 1.0 1.71 (0.78–2.99) 4.12 (2.13–7.98)f 3.05 (1.63–5.78)
Advanced, n (%) 14 (18.2) 8 (10.4) 55 (71.4) 63 (81.8)
OR (95% CI)a 1.0 0.62 (0.22–1.70) 3.71 (1.80–7.53)g 2.28 (1.12–4.49)
   Postmenopausal     
Controls, n (%) 110 (35.0) 55 (17.5) 149 (47.5) 204 (65.0)
Cases by stage     
Local, n (%) 49 (21.5) 52 (22.8) 127 (55.7) 179 (78.5)
OR (95% CI)a 1.0 2.15 (1.28–3.75) 1.94 (1.26–2.98)h 1.88 (1.20–2.59)
Advanced, n (%) 28 (21.2) 30 (22.7) 74 (56.1) 104 (78.8)
OR (95% CI)a 1.0 2.16 (1.15–4.22) 1.98 (1.19–3.36)i 2.00 (1.18–3.29)
  1. aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, use of non-steroidal anti-inflammatory drugs (NSAID), alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. bP for trend = 0.31; cP for trend = 0.02; d, e , f, g, h, iP for trend = 0.003.