CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

Table 6 Associations between GSTP1 genotype and breast cancer

	Ile/Ile	Ile/Val	Val/Val	Ile/Val and Val/Val
All
Cases, n (%)	315 (57.6)	217 (39.7)	15 (2.7)	232 (42.4)
Controls, n (%)	128 (23.5)	340 (62.5)	76 (14.0)	416 (76.5)
OR (95% CI)^a	1.0	0.22 (0.14–0.30)	0.04 (0.01–0.09)^b	0.15 (0.07–0.25)
Menopausal status at diagnosis
Premenopausal
Cases, n (%)	101 (54.0)	76 (40.6)	10 (5.4)	86 (46.0)
Controls, n (%)	58 (25.2)	140 (60.9)	32 (13.9)	172 (74.8)
OR (95% CI)^a	1.0	0.27 (0.17–0.38)	0.14 (0.06–0.22)^b	0.23 (0.16–0.35)
Postmenopausal
Cases, n (%)	214 (59.4)	141 (39.2)	5 (1.4)	146 (40.6)
Controls, n (%)	70 (22.3)	200 (63.7)	44 (14.0)	244 (77.7)
OR (95% CI)^a	1.0	0.23 (0.14–0.35)	0.09 (0.02–0.10)^b	0.36 (0.24–0.55)

^aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. ^bP for trend = 0.001.

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