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Table 6 Associations between GSTP1 genotype and breast cancer

From: CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

  Ile/Ile Ile/Val Val/Val Ile/Val and Val/Val
All     
Cases, n (%) 315 (57.6) 217 (39.7) 15 (2.7) 232 (42.4)
Controls, n (%) 128 (23.5) 340 (62.5) 76 (14.0) 416 (76.5)
OR (95% CI)a 1.0 0.22 (0.14–0.30) 0.04 (0.01–0.09)b 0.15 (0.07–0.25)
Menopausal status at diagnosis     
   Premenopausal     
Cases, n (%) 101 (54.0) 76 (40.6) 10 (5.4) 86 (46.0)
Controls, n (%) 58 (25.2) 140 (60.9) 32 (13.9) 172 (74.8)
OR (95% CI)a 1.0 0.27 (0.17–0.38) 0.14 (0.06–0.22)b 0.23 (0.16–0.35)
   Postmenopausal     
Cases, n (%) 214 (59.4) 141 (39.2) 5 (1.4) 146 (40.6)
Controls, n (%) 70 (22.3) 200 (63.7) 44 (14.0) 244 (77.7)
OR (95% CI)a 1.0 0.23 (0.14–0.35) 0.09 (0.02–0.10)b 0.36 (0.24–0.55)
  1. aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. bP for trend = 0.001.