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Table 11 Risk's level according to genotypes combination

From: CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

 

Cases

Controls

   

Genotype

n

n

ORa

95% CI

P

Reference genotype

254

633

1.0

  

Intermediate risk

643

776

2.32

1.79–2.54

< 0.001

High risk

1291

767

4.22

3.55–5.02

< 0.001

  1. aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. ORs are calculated relative to subjects with the reference genotype.
  2. Reference genotype GSTP1ValVal-PON1/192RR-PON1/55LL-GLO1AA.
  3. Intermediate risk: GSTP1IleVal-PON1/192QR-PON1/55LM-GLO1AE.
  4. High risk: GSTP1IleIle-PON1/192QQ-PON1/55MM-GLO1EE.
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BMC Cancer

ISSN: 1471-2407

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