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Figure 12 | BMC Cancer

Figure 12

From: Activation of P2X7-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

Figure 12

Effects of BzATP in mouse wild-type normal keratinocytes on increases in cytosolic calcium (above baseline, ΔCa 2+ i ), in medium containing 1.2 mM Ca 2+ or 1.2 mM Ca 2+ plus 1.2 mM EGTA (A, C); and on the influx of ethidium bromide (Eth-Br, B, C). Ca2+ o: extracellular calcium. In A and B BzATP was added (arrows) at 100 μM. In C cells were treated with one of the indicated concentrations of BzATP for 8 hours. Levels of ΔCa2+ i (empty circles) were determined 2 min after adding BzATP; changes in Eth-Br fluorescence (filled circles) were determined 5 min after adding BzATP. Values in C are means (± SD). Experiments were repeated 3 times. AU – arbitrary units.

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