Prognostic scores in brain metastases from breast cancer

Table 4 Prognostic impact (PI) of different tumor- and patient-related parameters

	n	PI of hormone receptor status	PI of HER-2 status	PI of various factors (multivariate)
Claude et al. [10]	120	none	no data	performance status, lymphopenia
Bartsch et al. [16]	174	none	none	performance status, number of metast. sites
Le Scodan et al. [11]	117	receptor negative sign. worse	none	performance status, lymphopenia, hormone receptor status
Nam et al. [17]	126	receptor negative sign. worse	HER-2 negative sign. worse	number of metast. sites, age, hormone and HER-2 receptor status, leptomeningeal disease
Eichler et al. [18]	83	none	HER-2 negative sign. worse	HER-2 receptor status, number of brain metast., local disease control
Melisko et al. [19]	112	receptor negative sign. worse	none	hormone receptor status, age, performance status, stable or responding systemic disease
Harputluoglu et al. [20]	144	none	none	number of brain metast.
Park et al. [21]	125	none	HER-2 positive sign. worse	HER-2 receptor status, performance status
Altundag et al. [23]	420	receptor negative sign. worse	none	age, hormone receptor status
Wronski et al. [25]	70	receptor negative sign. worse	no data	leptomeningeal disease, combined surgery and whole brain radiotherapy
Lee et al. [22]	198	no data	no data	performance status, number of brain metast.
Viani et al. [9]	174	no data	no data	extracranial metastases, RPA class
Mahmoud-Ahmed et al. [12]	116	no data	no data	performance status
Liu et al. [24]	48	no data	no data	performance status, number of brain met.