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Table 6 Activity of fotemustine according to the MGMT promoter methylation status

From: Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation

 

Methylated MGMT

Unmethylated MGMT

Total pts

Partial Response

3 (1 GBM, 2 AA)

-

3

Stable Disease

5 (3 GBM, 2 AA)

-

5

Progression

4 (2 GBM, 2 AA)

7 (4 GBM, 2 AA, 1 AOA)

11

Total pts

12

7

19

  1. AA, anaplastic astrocytoma; AOA, anaplastic oligoastrocytoma, AOD, anaplastic oligodendroglioma; GBM, glioblastoma multiforme; MGMT, methylguanine methyltransferase; pts, patients