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Figure 4 | BMC Cancer

Figure 4

From: RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells

Figure 4

c-MYC siRNA-mediates inhibition of hTERT mRNA expression and telomerase activity. Inhibition of hTERT mRNA expression (A) and telomerase activity (B, C) by c-MYC down-regulation as determined by quantitative RT-PCR (A), by the TRAP assay showing typical products of telomerase activity (6-nucleotide telomerase product ladder) with bands starting from 50 bp and the internal control (IC) in a single band of 216 bp (B), and by the TeloTAGGG telomerase polymerase chain reaction (PCR) enzyme-linked immunosorbent assay (ELISA) kit (C). Values represent the percentage of hTERT mRNA (n = 3; ± SD) and mean absorbance (n = 3; ± SD) of control and c-MYC siRNA-transfected cells (A, C).

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