Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent

Table 3 Frequency of double haplotypes

		Double haplotype frequencies (%)									P value
Group	Sample number	-G -G	-G +G	-G -C	-G +C	+G -C	+G +C	-C -C	-C +C	+C +C	All cases	BRCA2+	BRCA-
Controls	112	55 (49.1)	2 (1.8)	21 (18.8)	25 (22.3)	0	0	2 (1.8)	6 (5.4)	1 (1.0)	0.98
All cases	157	74 (47.1)	5 (3.2)	26 (16.6)	40 (25.5)	1 (0.6)	1 (0.6)	2 (1.2)	7 (4.5)	1 (0.6)
BRCA1+	42	18 (42.9)	2 (4.8)	7 (16.7)	11 (26.2)	0	0	1 (2.4)	3 (7.1)	0		0.94	0.61
BRCA2+	57	26 (45.6)	2 (3.5)	12 (21.1)	11 (19.3)	1 (1.8)	1 (1.8)	0	3 (5.3)	1 (1.8)			0.34
BRCA-	58	30 (51.7)	1 (1.7)	7 (12.1)	18 (31.0)	0	0	1 (1.7)	1 (1.7)	0
BRCA1/2+	99	44 (44.4)	4 (4.0)	19 (19.2)	22 (22.2)	1 (1.0)	1 (1.0)	1 (1.0)	6 (6.1)	1 (1.0)			0.61

ISSN: 1471-2407