Figure 2

Scatter plots of the ages at diagnoses of breast cancer based on BRCA mutation status and the double haplotypes observed for the TP53 polymorphisms. Shown are the distributions of ages of diagnosis based on BRCA mutation status and TP53 polymorphism double haplotypes based on 72Arg [G], 72Pro [C], Ins16 [+] and Ins16minus [-] alleles. For the BRCA1 mutation-positive groups, the [-G; -G] carriers (n = 18) had a mean age ± st. err. = 42.6 ± 2.1; the [-G; +G] carriers (n = 2) had a mean age ± st. err. = 56.5 ± 6.5; the [-G; -C] carriers (n = 7) had a mean age ± st. err. = 41.9 ± 4.3; the [-G; +C] carriers (n = 11) mean age ± st. err. = 46.1 ± 2.5; the [-C; -C] carrier (n = 1) had a age = 27; and the [-C; +C] carriers (n = 3) had a mean age ± st. err. = 43.7 ± 7.2. For the BRCA2 mutation-positive carriers, the [-G; -G] carriers (n = 26) had a mean age ± st. err. = 43.5 ± 1.6; the [-G; +G] carriers (n = 2) had a mean age ± st. err. = 33.5 ± 1.5; the [-G; -C] carriers (n = 12) had a mean age ± st. err. = 41.8 ± 2.8; the [-G; +C] carriers (n = 11) had a mean age ± st. err. = 38.4 ± 1.6; the [+G; -C] carrier (n = 1) had a age = 42; the [+G; +C] carrier (n = 1) had a age = 54; the [-C; +C] carriers (n = 3) had a mean age ± st. err. = 52.0 ± 6.6; and the [+C; +C] carrier (n = 1) had a age = 56. For the BRCA mutation-negative group, the [-G; -G] carriers (n = 30) had a mean age ± st. err. = 48.2 ± 1.6; the [-G; +G] carrier (n = 1) had an age = 45; the [-G; -C] carriers (n = 7) had a mean age ± st. err. = 45.1 ± 3.9; the [-G; +C] carriers (n = 18) had a mean age ± st. err. = 46.4 ± 1.5; the [-C; -C] carrier (n = 1) had an age = 37; and the [-C; +C] carrier (n = 1) had an age = 59.