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Table 1 IC50 values for lovastatin, mevastatin and simvastatin (± std. deviation)

From: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells

Cell Line

IC50 Lovastatin (μM)

IC50 Mevastatin (μM)

IC50 Simvastatin (μM)

Lung cancer

   

DLRP

1.7 ± 0.5

1.9 ± 0.1

0.9 ± 0.1

H1299

2.6 ± 0.4

5.1 ± 0.3

1.3 ± 0.2

Melanoma

   

HT144

1.7 ± 0.12

2.0 ± 0.33

1.0 ± 0.10

M14

1.2 ± 0.05

1.9 ± 0.10

0.8 ± 0.05

SK-MEL-28

1.3 ± 0.15

2.1 ± 0.11

0.8 ± 0.11

Breast cancer

   

BT474A

5.3 ± 0.8

11.1 ± 1.5

4.2 ± 1.8

SKBR-3

4.7 ± 1.6

4.3 ± 0.6

2.2 ± 0.3

MDA-MB-453

7.8 ± 1.2

12.2 ± 3.5

5.4 ± 1.0

BT-20

3.9 ± 2.5

4.8 ± 1.6

1.7 ± 0.7