Figure 1From: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cellsInduction of apoptosis in M14 melanoma cells by statins. M14 cells were exposed to statin treatment for 72 hours. Taxol (0.1 μM) was used as a positive control for apoptosis induction. Apoptosis was measured using an annexin V assay on the Guava EasyCyte, and results presented as % early and late apoptotic cells. (Lova = Lovastatin, Meva = Mevastatin, Simva = Simvastatin). Error bars represent std error of the mean for triplicate experiments. * indicates p < 0.05 using the Student's t-test to compare levels of late apoptosis in statin treated cells versus control.Back to article page