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Table 1 Presentation of the positivity indices (PI) of CD34, SMA and VEGF among the histological groups of study, in relation to MVD. CD34 and SMA reactivities are graded as negative (n), intermediate (i) and positive (p). VEGF expression is evaluated by the product of staining intensity score multiplied with the percentage of the staining area score. This product is graded as low (L), intermediate (I) and high (H).

From: The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions

STAINING CD34 (n) CD34 (i) CD34 (p) CD34 (PI) SMA (n) SMA (i) SMA (p) SMA (PI) VEGF (L) VEGF (I) VEGF (H) VEGF (PI) MVD Mean(vessel number/mm2) ± SD
NORMAL (n = 20) 0 0 20 1 16 4 0 0.2 18 2 0 0.1 86 ± 3
HUT (n = 32) 0 0 32 1 30 2 0 0.062 32 0 0 0 79 ± 7
ADH (n = 22) 1 1 20 0.954 21 1 0 0.045 13 3 6 0.409 119 ± 10
FA (n = 8) 0 1 7 1 7 0 1 0.125 4 2 2 0.5 114 ± 9
DCIS-L (n = 21) 0 4 17 1 14 6 1 0.333 5 12 4 0.761 121 ± 13
DCIS-I (n = 24) 8 5 11 0.667 0 11 13 1 5 14 5 0.791 140 ± 32
DCIS-H (n = 33) 25 5 3 0.242 0 0 33 1 6 11 16 0.818 146 ± 38
ALH (n = 11) 0 0 11 1 11 0 0 0 11 0 0 0 109 ± 5
LCIS (n = 25) 0 1 24 1 22 3 0 0.12 15 9 1 0.4 111 ± 7