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Table 4 Univariate and multivariate Cox survival analysis

From: Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer

Univariate

   

Variables

p

HR

OS (95% CI)

Menopausal Status

0.215

0.958

(0.772–1.188)

Tumor Size

0.029

1.569

(1.264–1.946)

Lymph Node Status

< 0.001

2.198

(1.860–2.596)

Histological Grade

0.045

1.438

(1.072–1.929)

ER

0.091

0.778

(0.579–1.042)

PR

0.046

0.687

(0.565–0.836)

Her-2/neu

< 0.001

1.989

(1.684–2.349)

High Tumor MMP-13

0.007

1.357

(1.171–1.571)

High Stromal Fibroblast MMP-13

0.146

0.995

(0.786–1.259)

High Tumor-derived MMP-2

0.443

1.276

(0.969–1.678)

High Tumor-derived MMP-9

0.889

1.245

(0.984–1.575)

High Tumor-derived TIMP-1

0.023

1.278

(1.103–1.480)

High Tumor-derived TIMP-2

0.881

1.072

(0.842–1.364)

Multivariate

   

Histological Grade

0.041

1.441

(1.074–1.933)

Lymph Node Status

< 0.001

2.199

(1.861–2.598)

Her-2/neu

< 0.001

1.98

(1.685–2.350)

Tumor Size

0.024

1.570

(1.266–1.948)

High Tumor MMP-13

0.006

1.565

(1.178–1.581)

High Tumor TIMP-1

0.021

1.281

(1.106–1.484)

  1. HR: Hazard Risk in Cox proportional hazard model analysis. HR > 1.0 means positive correlation with risk. HR < 1.0 means negative correlation with risk.