BMC Cancer

Table 2 Correlation of high MMP-13 expression with clinicopathological parameters and other biomarkers

From: Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer

		High MMP-13 expression
		Cancer Cells			Stromal Fibroblasts
Parameters/Markers	Total	n	%	p	n	%	p
Menopausal
Pre-menopausal	132	64	48.5	0.949	70	53.0	0.573
Post-menopausal	131	63	48.1		71	56.5
Tumor Size
<2 cm	46	25	54.3	0.365	28	60.9	0.359
>2 cm	217	102	47.0		116	53.5
Lymph Node Status
N0	128	43	33.6	< 0.001	55	43	< 0.001
N1	57	25	43.9		31	54.4
N2	26	17	65.4		16	61.5
N3	52	42	80.8		42	80.8
Histological Grade	68	22	32.35	0.001	27	39.7	0.071
G1	119	56	47.06		67	56.3
G2	76	49	64.47		51	54.8
G3
ER Status	101	51	50.5	0.572	56	55.4	0.859
Negative	162	76	46.9		88	54.3
Positive
PR Status	101	85	52.5	0.086	95	58.6	0.109
Negative	162	42	41.6		49	485
Positive
HER2/neu Protein	211	94	44.5	0.0150	101	47.9	< 0.001
Negative	52	33	63.5		43	82.7
Positive
MMP-2 Protein	171	81	47.4	0.234	96	56.1	0.927
Negative	51	29	56.9		29	56.9
Positive
MMP-9 Protein	162	88	54.3	0.911	81	50.0	0.367
Negative	58	32	55.2		42	43.3
Positive
TIMP-1 expression	131	50	38.2	< 0.001	63	48.8	0.002
Negative	72	52	72.2		51	70.8
Positive
TIMP-2 Protein	41	15	36.6	0.080	52	35.6	0.029
Negative	142	74	52.1		34	51.5
Positive

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ISSN: 1471-2407

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