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Table 2 Correlation of high MMP-13 expression with clinicopathological parameters and other biomarkers

From: Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognosis of invasive breast cancer

   High MMP-13 expression
   Cancer Cells Stromal Fibroblasts
Parameters/Markers Total n % p n % p
Menopausal        
   Pre-menopausal 132 64 48.5 0.949 70 53.0 0.573
   Post-menopausal 131 63 48.1   71 56.5  
Tumor Size        
   <2 cm 46 25 54.3 0.365 28 60.9 0.359
   >2 cm 217 102 47.0   116 53.5  
Lymph Node Status        
   N0 128 43 33.6 < 0.001 55 43 < 0.001
   N1 57 25 43.9   31 54.4  
   N2 26 17 65.4   16 61.5  
   N3 52 42 80.8   42 80.8  
Histological Grade 68 22 32.35 0.001 27 39.7 0.071
   G1 119 56 47.06   67 56.3  
   G2 76 49 64.47   51 54.8  
   G3        
ER Status 101 51 50.5 0.572 56 55.4 0.859
   Negative 162 76 46.9   88 54.3  
   Positive        
PR Status 101 85 52.5 0.086 95 58.6 0.109
   Negative 162 42 41.6   49 485  
   Positive        
HER2/neu Protein 211 94 44.5 0.0150 101 47.9 < 0.001
   Negative 52 33 63.5   43 82.7  
   Positive        
MMP-2 Protein 171 81 47.4 0.234 96 56.1 0.927
   Negative 51 29 56.9   29 56.9  
   Positive        
MMP-9 Protein 162 88 54.3 0.911 81 50.0 0.367
   Negative 58 32 55.2   42 43.3  
   Positive        
TIMP-1 expression 131 50 38.2 < 0.001 63 48.8 0.002
   Negative 72 52 72.2   51 70.8  
   Positive        
TIMP-2 Protein 41 15 36.6 0.080 52 35.6 0.029
   Negative 142 74 52.1   34 51.5  
   Positive