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Table 7 Survival in trials comparing gemcitabine to gemcitabine plus fluoropyrimidine

From: Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer

Reference Year Treatment regimen Median survival (mo) p HR 95% CI
Berlin 2002 Gemcitabine 5.4 0.09 0.82 0.65 – 1.03
   Gemcitabine + 5-FU (bolus) 6.7    
Riess 2005 Gemcitabine 6.2 0.68 1.04 0.86 – 1.25
   Gemcitabine + 5-FU (infusional) 5.9    
DiCostanzo 2005 Gemcitabine 7.8 -- na na
   Gemcitabine + 5-FU (CI) 7.5    
Scheithauer 2003 Gemcitabine 8.2 -- 0.82 0.50 – 1.35
   Gemcitabine + Capecitabine 9.5    
Herrmann 2005 Gemcitabine 7.3 0.314 0.89 0.70 – 1.12
   Gemcitabine + Capecitabine 8.4    
Cunningham 2005 Gemcitabine 6.0 0.026 0.79 0.65 – 0.97
   Gemcitabine + Capecitabine 7.4    
  1. 5-FU: 5-fluorouracil; CI = continuous infusion; na = data not available;