Reference | Year | n | Treatment regimen | ORR (%) | p | Median PFS/TTP (mo) | p |
---|---|---|---|---|---|---|---|
Berlin | 2002 | 162 | Gemcitabine | 5.6 | -- | 2.2 | Â |
 |  | 160 | Gemcitabine + 5-FU (bolus) | 6.9 |  | 3.4 | 0.022 |
Riess | 2005 | 238 | Gemcitabine | 7.2 | -- | 3.5 | 0.44 |
 |  | 235 | Gemcitabine + 5-FU (infusional) | 4.8 |  | 3.5 |  |
DiCostanzo | 2005 | 48 | Gemcitabine | 8 | -- | 3.5 | -- |
 |  | 43 | Gemcitabine + 5-FU (CI) | 11 |  | 4.5 |  |
Scheithauer | 2003 | 42 | Gemcitabine | 14 | -- | 4.0 | -- |
 |  | 41 | Gemcitabine + Capecitabine | 17 |  | 5.1 |  |
Herrmann | 2005 | 159 | Gemcitabine | 7.9 | -- | 4.0 | 0.207 |
 |  | 160 | Gemcitabine + Capecitabine | 10.1 |  | 4.8 |  |
Cunningham | 2005 | 266 | Gemcitabine | 7.1 | 0.008 | na | na |
 |  | 267 | Gemcitabine + Capecitabine | 14.2 |  | na |  |