Reference | Year | n | Treatment regimen | Stage IV (%) | Male (%) | PS 0–1 (%) |
---|---|---|---|---|---|---|
Louvet | 2005 | 156 | Gem 1000 mg/m2 for 7 of 8 wks, then wkly for 3 of 4 wks | 70 | 53 | 82 |
 |  | 157 | Gem 1000 mg/m2/100 min d1 (FDR) + Oxaliplatin 100 mg/m2 d2 q 2 wks | 68 | 60 | 83 |
Poplin | 2006 | 279 | Gem 1000 mg/m2 for 7 of 8 wks, then wkly for 3 of 4 wks (standard) | 88 | 56 | 88 |
 |  | 277 | Gem 1500 mg/m2/150 min q wk × 3 of 4 wks (FDR) |  | 58 |  |
 |  | 276 | Gem 1000 mg/m2/100 min d1 (FDR) + Oxaliplatin 100 mg/m2 d2 q 2 wks |  | 46 |  |
Heinemann | 2006 | 97 | Gem 1000 mg/m2 for 3 of 4 wks | 79 | 62 | 49* |
 |  | 98 | Gem 1000 mg/m2 + Cisplatin 50 mg/m2 q 2 wks | 80 | 65 | 56* |
Colucci | 2002 | 54 | Gem 1000 mg/m2 for 7 of 8 wks, then wkly for 3 of 4 wks | 54 | 50 | med. KPS 70 |
 |  | 53 | Gem 1000 mg/m2 + Cisplatin 25 mg/m2 for 6/7 wks | 62 | 66 | med. KPS 70 |
Viret | 2004 | 41 | Gem 1000 mg/m2 for 7 of 8 wks, then wkly for 3 of 4 wks | 78 | na | 83 |
 |  | 42 | Gem 1000 mg/m2 d1, 8, 15 + Cisplatin 75 mg/m2 d15 q 4 wks | 81 | na | 76 |