Figure 3

Effects of alendronate treatment on morphology and on immunohistochemical staining of markers of proliferation (Ki-67), apoptosis (ISEL) and angiogenesis (CD34) in orthotopic PC-3 prostate tumors and lymph nodes. Alendronate treatment increased apoptosis in tumors and prostate draining lymph nodes and decreased angiogenesis in tumors (Bar = 100 μm). * Significantly different from PBS-treated control, p < 0.05, *** significantly different from PBS-treated control, p < 0.001, NS nonsignificant (Student's t-test).