Morphology of orthotopic PC-3 prostate tumors and metastases in prostate draining lymph nodes. Prostate from sham-operated control mice (A) and tumor bearing mice (B) 4 weeks after inoculation of PC-3 cells (tumor tissue, arrows). DD = ductus deferens, DP = dorsal prostate, SV = seminal vesicle, T = tumor tissue, U = urethra, VP = ventral prostate (Bar = 500 μm). Prostate draining lymph nodes of sham-operated control mice (C) and from prostate tumor bearing mice (D and E). Infiltrating tumor cells were first observed in the sub-capsular areas of lymph nodes (arrows, D) and in advantaged cases cortex and medulla (arrows, E). Cap = lymph node capsule, (Bar = 500 μm).