Chemoradiation period (n = 31) | Consolidation chemotherapy period (n = 21) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Acute Toxicity | Grade (No. of patients) | Incidence of ≥ Grade 3 | Grade (No. of patients) | Incidence of ≥ Grade 3 | ||||||
1 | 2 | 3 | 4 | (%) | 1 | 2 | 3 | 4 | (%) | |
Hematological | ||||||||||
Neutopenia | 2 | 3 | 3 | 0 | 9.7 | 0 | 3 | 2 | 5 | 33.3 |
Anemia | 5 | 6 | 1 | 0 | 3.2 | 2 | 4 | 0 | 0 | 0 |
Thrombocytopenia | 0 | 0 | 2 | 0 | 6.5 | 0 | 0 | 0 | 2 | 9.5 |
Febrile neutropenia | 0 | 0 | 2 | 0 | 6.5 | 0 | 0 | 2 | 0 | 9.5 |
Non-hematological | ||||||||||
Stomatitis | 1 | 4 | 0 | 0 | 0 | 3 | 4 | 0 | 0 | 0 |
Diarrhea | 3 | 9 | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 0 |
Constipation | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nausea/vomiting | 3 | 16 | 0 | 0 | 0 | 3 | 7 | 0 | 0 | 0 |
Asthenia | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.8 |
Abdominal pain | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Infection | 0 | 2 | 1 | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 |
Dermatitis | 3 | 6 | 17 | 0 | 54.8 | 0 | 0 | 0 | 0 | 0 |