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Table 4 Clinico-pathologic, DNA, RNA, and protein analysis of CDKN1C in six cases with breast cancer

From: CDKN1C/p57kip2is a candidate tumor suppressor gene in human breast cancer

Case number

225

248

266

271

277

285

Age (years)

40

48

46

39

56

50

Histology

D

D

D

D

D

D

Grade (out of 3)

3

2

3

3

3

2

ER/PR

+/+

+/+

+/+

+/+

-/-

+/+

Her2/neu

+

-

-

-

-

-

DNA – analysis of AI/LOH

      

11p15.4-.5

-

-

-

-

+

 

CDKN1C

-

 

-

-

  

mRNA – % of normal CDKN1C expression

     
 

37

2

45

32

4

13

Protein – staining for CDKN1C

      

Myoepithelium

      

   Normal

-

-

+

+

+

+

   CIS

-

-

 

-

 

-

   IC*

      

Luminal epithelium

      

   Normal

+

+/-

-

-

-

-

   CIS

+

-

 

-

 

-

   IC

 

-

-

-

-

-

  1. D, ductal histology; blank box, not available.
  2. +, positive staining, amplification or AI/LOH;
  3. -, negative staining, amplification or no AI/LOH.
  4. CIS, carcinoma in situ; IC, invasive carcinoma.
  5. *By definition invasive carcinoma does not have a myoepithelium
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BMC Cancer

ISSN: 1471-2407

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