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Table 1 Characteristics of NSLN- and NSLN+ cases among SLN+ patients (Bay Area SLN Database).

From: New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients

  Tumor-free NSLN Tumor-involved NSLN Univariate P Multivariate P ∫∫ %NSLN+ (NSLN+/SLN+) TOTAL SLN+
Patient and Tumor Characteristics Number of Pts (n = 184) % Mean SEM* Number of Pts (n = 101) % Mean SEM*     Number of Pts (n = 285) %
Patient Age (years)    55.8 0.89    53 1.14 0.084 NA    
Tumor Type              
   Infiltrating Ductal Carcinoma 159 86    87 86    0.781 NA 35% 246 86.3
   Invasive Lobular Carcinoma 18 10    9 9      33% 27 9.5
   Mixed Carcinoma 6 3    5 5      45% 11 3.9
   Tubular Carcinoma 1 1    0 0      0% 1 0.4
Tumor size (cm)    2.11 0.1    2.97 0.18 <0.001 <0.001    
Tumor size (AJCC)          0.001 0.045    
   T1 117 64    39 39      25% 156 54.7
T1a (mic) 1 1    0 0      0% 1 0.4
T1a 6 3    2 2      25% 8 2.8
T1b 19 10    3 3      14% 22 7.7
T1c 91 49    34 34      27% 125 43.9
   T2 59 32    50 50      46% 109 38.2
   T3 8 4    12 12      60% 20 7.0
Tumor grade†          0.001 0.736    
   G1: Nottingham combined histologic score 3–5 68 37    23 23      25% 91 31.9
   G2: Nottingham combined histologic score 6–7 81 44    39 39      33% 120 42.1
   G3: Nottingham combined histologic score 8–9 35 19    39 39      53% 74 26.0
ER status          0.004 0.079    
   Negative 17 9    21 21      55% 38 13.3
   Positive 134 73    60 59      31% 194 68.1
   Unknown 33 18    20 20      38% 53 18.6
PR status          0.015 0.869    
   Negative 35 19    31 31      47% 66 23.2
   Positive 116 63    50 50      30% 166 58.2
   Unknown 33 18    20 20      38% 53 18.6
HER2/neu expression          0.256 NA    
   Not overexpressed, 0+ or 1+ 81 44    38 38      32% 119 41.8
   Equivocal, weak overexpression, 2+ 2 1    2 2      50% 4 1.4
   Overexpressed, 3+ 29 16    23 23      44% 52 18.2
   Unknown 72 39    38 38      35% 110 38.6
Angiolymphatic invasion          <0.001 <0.001    
   None 95 52    23 23      19% 118 41.4
   Present 25 14    70 69      74% 95 33.3
   Unknown 64 35    8 8      11% 72 25.3
Sentinel Lymph Node Characteristics              
No. SLNs Removed    1.96 0.07    1.87 0.09 0.511 NA    
   = 1 71 39    42 42    0.806   37% 113 39.6
   = 2 67 36    37 37      36% 104 36.5
   >2 46 25    22 22      32% 68 23.9
No. SLNs Tumor-involved    1.33 0.05    1.39 0.07 0.426 NA    
   = 1 137 73    71 70    0.679   34% 208 73.0
   = 2 38 21    23 23      38% 61 21.4
   >2 9 6    7 7      44% 16 5.6
Size of SLN metastases§          <0.001 <0.001    
   Isolated tumor cells or clusters ≤ 0.2 mm 61 33    3 3      4.7% 64 22.5
   Micrometastases, >0.2 mm to 2 mm 117 64    83 82      42% 200 70.2
   Macrometastases, >2 mm 6 3    15 15      71% 21 7.4
Sentinel lymph node metastases identification          <0.001 NA    
   Hematoxylin and eosin staining 122 61    98 97      45% 220 77.2
   Immunohistochemistry 62 34    3 3      4.6% 65 22.8
  1. ∫ Univariate analyses calculated by χ 2 test and Wilcoxon rank sum test.
  2. ∫∫ Multivariate analyses calculated by logistic regression of significant factors by univariate analysis.
  3. *SEM, standard error of the mean.
  4. †Determined according to modified Scarff-Bloom-Richardson grading system.
  5. §Determined according to AJCC criteria, 6th ed.
  6. NA, variable not included in multivariate analysis (not an independent factor or not significant in univariate analysis)