Skip to main content

Table 5 Percentages of cells in the polyploid cell cycle.

From: Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro

Cell line

Control

24 h

48 h

24+24

24+48

 

Percentage of cells in S2

 

VRL

    

ECV304

1.5 ± 0.2

5.5 ± 0.9a

18.5 ± 1.2a *

17.6 ± 2.3b

20.1 ± 0.9b

CAL-27

1.3 ± 0.1

5.6 ± 1.6

22.9 ± 1.5a

12.3 ± 1.4b

20.2 ± 0.9b

MCF-7

2.2 ± 0.5

2.9 ± 0.8

9.7 ± 3.9

4.4 ± 0.6

8.6 ± 0.5b

H292

1.4 ± 0.4

3.0 ± 1.0

7.9 ± 1.4a

3.4 ± 0.7

5.7 ± 0.9

 

VFL

    

ECV304

1.3 ± 0.2

7.6 ± 1.3a

22.4 ± 0.8a

12.6 ± 1.1b

16.2 ± 0.6b

CAL-27

1.7 ± 0.5

4.3 ± 1.0

21.8 ± 1.4a

11.8 ± 0.7

21.8 ± 0.8b

MCF-7

2.0 ± 0.3

2.8 ± 1.0

8.8 ± 1.6a

5.2 ± 0.4

10.6 ± 1.1b

H292

1.0 ± 0.2

2.9 ± 0.5a

7.1 ± 0.9a

3.6 ± 1.2

4.5 ± 0.5

 

Percentage of cells in (G2/M)2

 

VRL

    

ECV304

0.3 ± 0.0

1.2 ± 0.2a

12.2 ± 1.5a

9.8 ± 1.6b

10.2 ± 1.3b

CAL-27

0.4 ± 0.1

2.2 ± 0.6

37.4 ± 4.8a

4.8 ± 0.5b

6.1 ± 0.9b

MCF-7

0.5 ± 0.1

1.3 ± 0.3

2.1 ± 0.5

2.1 ± 0.7

3.4 ± 0.2b

H292

0.3 ± 0.1

1.1 ± 0.3

6.5 ± 1.0a

1.4 ± 0.2

2.2 ± 0.2b

 

VFL

    

ECV304

0.2 ± 0.0

0.8 ± 0.3

15.6 ± 0.8a

8.5 ± 1.3b

9.2 ± 1.1b

CAL-27

0.3 ± 0.1

2.1 ± 0.5

41.8 ± 4.9a

5.4 ± 0.4

7.5 ± 0.5b

MCF-7

0.5 ± 0.1

1.3 ± 0.2a

4.4 ± 0.8a

2.0 ± 0.5

4.4 ± 0.4b

H292

0.2 ± 0.0

1.2 ± 0.2a

7.0 ± 0.9a

1.9 ± 0.4

2.4 ± 0.3b

  1. Percentages of cells in the polyploid cell cycle: at different incubation times with VRL or VFL and at different times after drug removal; mean ± standard error.
  2. a p < 0.05 compared to control
  3. b p < 0.05 compared to 24 h incubation
  4. * p < 0.05 compared to equitoxic VFL conc.