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Table 4 Percentages of cells in the G2/M phase of the cell cycle at different time points.

From: Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro

 

% of cells in G2/M

Cell line

Control

24+0 h

24+3 h

24+24 h

24+48 h

24+72 h

 

VRL

     

ECV304

18.1 ± 0.9

70.3 ± 2.1a

56.0 ± 5.8b *

32.6 ± 1.6b

25.1 ± 0.8c

21.4 ± 1.5c

CAL-27

14.4 ± 1.2

56.0 ± 1.1a

30.7 ± 3.3b

23.2 ± 1.3b

21.5 ± 0.6

24.3 ± 2.3

MCF-7

17.8 ± 1.2

53.5 ± 0.9a

28.1 ± 4.4b

35.1 ± 3.5b

33.1 ± 0.3

28.6 ± 3.2

H292

13.3 ± 0.8

64.0 ± 4.2a

41.9 ± 1.2b

40.1 ± 1.5b

37.1 ± 1.4

27.1 ± 1.5c

 

VFL

     

ECV304

17.6 ± 0.9

47.3 ± 6.9a

28.2 ± 2.3b

31.8 ± 1.7b

27.8 ± 1.1

23.4 ± 1.7c

CAL-27

13.5 ± 0.5

55.7 ± 6.6a

31.8 ± 3.6b

24.5 ± 2.0b

25.0 ± 0.7

27.6 ± 1.0

MCF-7

17.2 ± 1.0

53.3 ± 5.8a

36.2 ± 3.8

27.8 ± 3.4b

27.3 ± 3.1

29.8 ± 3.3

H292

11.9 ± 1.4

65.7 ± 1.1a

39.5 ± 1.0b

41.3 ± 2.3b

41.0 ± 2.5

26.9 ± 3.9c

  1. Percentages of cells in the G2/M phase of the cell cycle: at different time points after a 24 h incubation with VRL or VFL; mean ± standard error.
  2. a p < 0.05 compared to control
  3. b p < 0.05 compared to 24+0 h
  4. c p < 0.05 compared to 24+24 h
  5. * p < 0.05 compared to equitoxic VFL conc.