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Table 3 Percentages of cells in the G2/M phase of the cell cycle at different incubation times.

From: Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro

 

% of cells in G2/M

Cell line

Control

4 h incub.

6 h incub.

16 h incub.

20 h incub.

24 h incub.

48 h incub.

 

VRL

      

ECV304

22.5 ± 1.3

37.7 ± 1.7a

45.4 ± 2.0a

58.2 ± 4.3a

53.9 ± 6.9a

58.7 ± 6.5a

46.4 ± 6.2

CAL-27

17.9 ± 1.0

33.3 ± 1.0a

40.3 ± 1.6a

66.9 ± 5.6a

61.9 ± 3.9a

64.3 ± 4.2a

23.7 ± 3.0b

MCF-7

18.1 ± 1.2

23.2 ± 1.0a

27.8 ± 1.5a

46.3 ± 3.6a *

39.6 ± 2.0a *

42.6 ± 2.6a

36.6 ± 2.3*

H292

18.2 ± 1.2

31.6 ± 3.6a

46.8 ± 5.9a

71.4 ± 1.7a

64.8 ± 4.4a

64.7 ± 7.5a

60.4 ± 3.1

 

VFL

      

ECV304

20.6 ± 1.4

32.7 ± 3.3a

37.9 ± 3.1a

64.1 ± 5.6a

44.9 ± 7.3a

48.7 ± 6.5a

42.4 ± 3.5

CAL-27

17.1 ± 1.5

33.7 ± 2.4a

40.9 ± 1.3a

61.2 ± 1.2a

63.0 ± 6.5a

62.7 ± 5.3a

21.3 ± 2.9b

MCF-7

18.7 ± 0.9

25.5 ± 1.8a

30.8 ± 2.2a

59.7 ± 1.0a

54.6 ± 3.2a

48.7 ± 5.9a

49.3 ± 2.9

H292

18.7 ± 1.1

37.8 ± 3.2a

38.5 ± 4.1a

65.4 ± 5.1a

66.0 ± 4.5a

69.4 ± 3.0a

65.7 ± 1.8

  1. Percentages of cells in the G2/M phase of the cell cycle: at different incubation times with VRL and VFL; mean ± standard error.
  2. a p < 0.05 compared to control
  3. b p < 0.05 compared to 24 h incubation
  4. * p < 0.05 compared to the equitoxic VFL concentration