Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro

BMC Cancer

Table 2 Cell cycle distributions after 24 h incubation with equitoxic concentrations of VRL and VFL.

Cell line	Contr	60 nM VFL	Equitoxic conc. VRL	150 nM VFL	Equitoxic conc. VRL
	% G1
ECV304	39.1 ± 1.9	36.3 ± 2.2	(10 nM) 38.6 ± 2.8	15.0 ± 3.4^a	(30 nM) 10.1 ± 1.6^a
CAL-27	56.4 ± 1.7	19.0 ± 1.0^a	(10 nM) 19.0 ± 3.4^a	9.2 ± 1.1^a	(30 nM) 8.1 ± 1.5^a
MCF-7	50.3 ± 1.5	19.1 ± 2.3^a	(8 nM) 18.0 ± 1.7^a	11.3 ± 3.1^a	(20 nM) 10.9 ± 1.8^a
H292	56.5 ± 0.9	39.3 ± 2.4^a	(15 nM) 25.6 ± 3.0^a *	15.0 ± 3.0^a	(40 nM) 9.3 ± 2.6^a
	% S
ECV304	38.6 ± 1.6	44.1 ± 2.9	(10 nM) 37.1 ± 1.6	26.4 ± 3.2^a	(30 nM) 17.4 ± 1.7^a
CAL-27	25.0 ± 1.1	33.3 ± 2.4	(10 nM) 31.0 ± 3.1	14.9 ± 1.9^a	(30 nM) 18.8 ± 2.6
MCF-7	26.2 ± 1.1	26.4 ± 1.4	(8 nM) 32.1 ± 2.0	29.7 ± 2.2	(20 nM) 32.1 ± 2.1^a
H292	23.4 ± 0.5	23.5 ± 1.0	(15 nM) 20.0 ± 2.8	23.8 ± 2.3	(40 nM) 18.2 ± 1.8^a
	% G2/M
ECV304	20.2 ± 1.0	19.2 ± 1.0	(10 nM) 19.6 ± 2.8	50.2 ± 1.7^a	(30 nM) 62.5 ± 2.9^a *
CAL-27	16.1 ± 0.7	30.4 ± 3.9^a	(10 nM) 32.8 ± 5.0^a	55.4 ± 3.3^a	(30 nM) 53.7 ± 2.4^a
MCF-7	20.3 ± 0.8	47.2 ± 6.1^a	(8 nM) 43.9 ± 1.6^a	52.5 ± 4.7^a	(20 nM) 52.2 ± 1.2^a
H292	17.8 ± 1.0	28.6 ± 1.3^a	(15 nM) 50.2 ± 5.0^a *	53.2 ± 6.8^a	(40 nM) 65.9 ± 5.0^a

Percentages of cells in the G1, S and G2/M phase of the cell cycle: after 24 h incubation with equitoxic concentrations of VRL and VFL; mean ± standard error.
^a p < 0.05 compared to control
* p < 0.05 compared to the equitoxic concentration of VFL

ISSN: 1471-2407