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Table 5 Genetic association estimates for GPX1(Pro200Leu) and EPHX1(His113Tyr) accounting for smoking

From: Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years

   

Relative chance for LC compared to ...

   

Genetic protected never or light smokers

Genetic protected of the same smoking exposure**.§

SEL: smoking exposure level

gPS*: count of protective alleles

n cases:controls

OR

95% CI

OR

95% CI

Never and light smoker

0

8:28

1.00

Reference

1.00

Reference

 

1

4:39

0.43

0.09 – 1.93

0.43

0.09 – 1.93

 

2

2:22

0.50

0.09 – 2.85

0.50

0.09 – 2.85

 

3 or 4

2:6

1.91

0.29 – 12.4

1.91

0.29 – 12.4

Moderate smokers

0

15:2

24.7

4.05 – 150

1.00

Reference

 

1

20:8

12.8

3.60 – 45.4

0.51

0.09 – 2.95

 

2

9:11

4.1

1.07 – 15.4

0.17

0.03 0.99

 

3 or 4

1:0

--

 

--

 

Heavy smokers

0

40:3

74.4

16.2 – 341

1.00

Reference

 

1

57:12

25.7

8.14 – 81.5

0.35

0.09 – 1.31

 

2

26:7

18.9

5.15 – 69.2

0.25

0.06 – 1.08

 

3 or 4

6:3

10.2

1.78 – 58.2

0.14

0.02 – 0.87

All smokers

0

   

1.00

Reference

 

1

   

0.40

0.14 – 1.15

 

2.3.4

   

0.20

0.07 – 0.60

  1. * no. protective alleles of GPX1(Pro200Leu) and EPHX1(His113Tyr)
  2. ** odds ratio. adjusted for sex and age
  3. § odds ratio of allele-carriers compared to non-carriers within the same smoking group
  4. SEL smoking exposure level: never and light smokers: ≤1 pack years. moderate smokers: 1-<20 pack years. heavysmokers: ≥20 pack years