| |
FOXP3
|
B7-H1
| ◇PD-1 |
|---|
| |
+
|
-
|
*P
|
+
|
-
|
P
|
+
|
-
|
P
|
|---|
|
Age
| | | | | | | | | |
|
< 40 years
|
15 (68)♣
|
7 (32)
|
1.000
|
12 (55)
|
10 (45)
|
0.595
|
15 (68)
|
7 (32)
|
0.583
|
|
≥ 40 years
|
27 (68)
|
13 (33)
| |
25 (63)
|
15 (34)
| |
22 (58)
|
16 (42)
| |
|
Tumor Size
| | | | | | | | | |
|
<4 CM
|
18 (55)
|
15 (45)
|
0.029
|
16 (48)
|
17 (52)
|
0.072
|
17 (53)
|
15 (47)
|
0.187
|
|
≥ 4 CM
|
24 (83)
|
5 (17)
| |
21 (72)
|
8 (28)
| |
20 (71)
|
8 (29)
| |
|
◆
Lymph Node Metastasis
| | | | | | | | | |
|
Negative
|
15 (75)
|
5 (25)
|
0.107
|
13 (65)
|
7 (35)
|
0.864
|
12 (63)
|
7 (37)
|
0.939
|
|
1 to 3
|
5 (42)
|
7 (58)
| |
6 (50)
|
6 (50)
| |
2 (29)
|
5 (71)
| |
|
4 to 9
|
12 (67)
|
6 (33)
| |
11 (61)
|
7 (39)
| |
12 (67)
|
6 (33)
| |
|
10 or more
|
9 (90)
|
1 (10)
| |
6 (60)
|
4 (40)
| |
5 (56)
|
4 (44)
| |
|
Histological Grade (SBR)
| | | | | | | | | |
|
II
|
14 (45)
|
17 (56)
|
<0.001
|
12 (39)
|
19 (61)
|
0.002
|
12 (40)
|
18 (60)
|
0.001
|
|
III
|
28 (90)
|
3 (10)
| |
25 (81)
|
6 (19)
| |
25 (83)
|
5 (17)
| |
|
Lymphovascular Invasion
| | | | | | | | | |
|
Positive
|
26 (70)
|
11 (30)
|
0.782
|
25 (68)
|
12 (32)
|
0.187
|
23 (64)
|
13 (36)
|
0.787
|
|
Negative
|
16 (64)
|
9 (36)
| |
12 (48)
|
13 (52)
| |
14 (58)
|
10 (42)
| |
|
Her2/neu status
| | | | | | | | | |
|
Positive
|
13 (62)
|
8 (38)
|
0.588
|
18 (62)
|
11 (38)
|
0.798
|
17 (61)
|
11 (39)
|
1.000
|
|
Negative
|
16 (64)
|
22 (58)
| |
19 (58)
|
14 (42)
| |
20 (63)
|
12 (38)
| |
|
ER status
| | | | | | | | | |
|
Positive
|
24 (57)
|
18 (43)
|
0.010
|
21 (50)
|
21 (50)
|
0.029
|
19 (48)
|
21 (53)
|
0.001
|
|
Negative
|
18 (90)
|
2 (10)
| |
16 (80)
|
4 (20)
| |
18 (90)
|
2 (10)
| |
|
PR status
| | | | | | | | | |
|
Positive
|
17 (57)
|
13 (43)
|
0.103
|
15 (50)
|
15 (50)
|
0.195
|
11 (38)
|
18 (62)
|
<0.001
|
|
Negative
|
25 (78)
|
7 (22)
| |
22 (69)
|
10 (31)
| |
26 (84)
|
5 (16)
| |
|
Neo-adjuvant Chemotherapy
| | | | | | | | | |
|
With
|
23 (64)
|
13 (36)
|
0.584
|
20 (56)
|
16 (44)
|
0.600
|
23 (66)
|
12 (34)
|
0.591
|
|
Without
|
19 (73)
|
7 (27)
| |
17 (65)
|
9 (35)
| |
14 (56)
|
11 (44)
| |
|
Lymphocyte Infiltration
| | | | | | | | | |
|
Focal
|
14 (52)
|
13 (48)
|
0.051
|
12 (44)
|
15 (56)
|
0.017
|
12 (46)
|
14 (54)
|
0.076
|
|
Moderate
|
14 (74)
|
5 (26)
| |
11 (58)
|
8 (42)
| |
13 (68)
|
6 (32)
| |
|
Severe
|
14 (88)
|
2 (13)
| |
14 (88)
|
2 (13)
| |
12 (80)
|
3 (20)
| |
|
B7-H1 expression of Tumor cells
| | | | | | | | | |
|
Positive
|
17 (89)
|
2 (11)
|
0.019
|
17 (89)
|
2 (11)
|
0.002
|
15 (83)
|
3 (17)
|
0.041
|
|
Negative
|
25 (58)
|
18 (42)
| |
20 (47)
|
23 (53)
| |
22 (52)
|
20 (48)
| |
-
Abbreviations: (+ and -) are number of positive and negative patients, ♣Numbers between brackets are the percentages of patients, ◆Two samples had unknown LN+ status, ◇Two samples had unknown PD-1 status *P values in bold represent a significant data.
