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Table 1 Correlation of FOXP3+ Tregs, B7-H1+ TIL and PD-1+ TIL with the clinicopathological parameters of 62 breast cancer patients

From: FOXP3+ Tregs and B7-H1+/PD-1+T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy

  FOXP3 B7-H1 PD-1
  + - *P + - P + - P
Age          
< 40 years 15 (68) 7 (32) 1.000 12 (55) 10 (45) 0.595 15 (68) 7 (32) 0.583
≥ 40 years 27 (68) 13 (33)   25 (63) 15 (34)   22 (58) 16 (42)  
Tumor Size          
<4 CM 18 (55) 15 (45) 0.029 16 (48) 17 (52) 0.072 17 (53) 15 (47) 0.187
≥ 4 CM 24 (83) 5 (17)   21 (72) 8 (28)   20 (71) 8 (29)  
Lymph Node Metastasis          
Negative 15 (75) 5 (25) 0.107 13 (65) 7 (35) 0.864 12 (63) 7 (37) 0.939
1 to 3 5 (42) 7 (58)   6 (50) 6 (50)   2 (29) 5 (71)  
4 to 9 12 (67) 6 (33)   11 (61) 7 (39)   12 (67) 6 (33)  
10 or more 9 (90) 1 (10)   6 (60) 4 (40)   5 (56) 4 (44)  
Histological Grade (SBR)          
II 14 (45) 17 (56) <0.001 12 (39) 19 (61) 0.002 12 (40) 18 (60) 0.001
III 28 (90) 3 (10)   25 (81) 6 (19)   25 (83) 5 (17)  
Lymphovascular Invasion          
Positive 26 (70) 11 (30) 0.782 25 (68) 12 (32) 0.187 23 (64) 13 (36) 0.787
Negative 16 (64) 9 (36)   12 (48) 13 (52)   14 (58) 10 (42)  
Her2/neu status          
Positive 13 (62) 8 (38) 0.588 18 (62) 11 (38) 0.798 17 (61) 11 (39) 1.000
Negative 16 (64) 22 (58)   19 (58) 14 (42)   20 (63) 12 (38)  
ER status          
Positive 24 (57) 18 (43) 0.010 21 (50) 21 (50) 0.029 19 (48) 21 (53) 0.001
Negative 18 (90) 2 (10)   16 (80) 4 (20)   18 (90) 2 (10)  
PR status          
Positive 17 (57) 13 (43) 0.103 15 (50) 15 (50) 0.195 11 (38) 18 (62) <0.001
Negative 25 (78) 7 (22)   22 (69) 10 (31)   26 (84) 5 (16)  
Neo-adjuvant Chemotherapy          
With 23 (64) 13 (36) 0.584 20 (56) 16 (44) 0.600 23 (66) 12 (34) 0.591
Without 19 (73) 7 (27)   17 (65) 9 (35)   14 (56) 11 (44)  
Lymphocyte Infiltration          
Focal 14 (52) 13 (48) 0.051 12 (44) 15 (56) 0.017 12 (46) 14 (54) 0.076
Moderate 14 (74) 5 (26)   11 (58) 8 (42)   13 (68) 6 (32)  
Severe 14 (88) 2 (13)   14 (88) 2 (13)   12 (80) 3 (20)  
B7-H1 expression of Tumor cells          
Positive 17 (89) 2 (11) 0.019 17 (89) 2 (11) 0.002 15 (83) 3 (17) 0.041
Negative 25 (58) 18 (42)   20 (47) 23 (53)   22 (52) 20 (48)  
  1. Abbreviations: (+ and -) are number of positive and negative patients, Numbers between brackets are the percentages of patients, Two samples had unknown LN+ status, Two samples had unknown PD-1 status *P values in bold represent a significant data.