Table 1 Correlation of FOXP3+ Tregs, B7-H1+ TIL and PD-1+ TIL with the clinicopathological parameters of 62 breast cancer patients
FOXP3 | B7-H1 | â—‡PD-1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
+ | - | *P | + | - | P | + | - | P | |
Age | |||||||||
< 40 years | 15 (68)♣ | 7 (32) | 1.000 | 12 (55) | 10 (45) | 0.595 | 15 (68) | 7 (32) | 0.583 |
≥ 40 years | 27 (68) | 13 (33) | 25 (63) | 15 (34) | 22 (58) | 16 (42) | |||
Tumor Size | |||||||||
<4 CM | 18 (55) | 15 (45) | 0.029 | 16 (48) | 17 (52) | 0.072 | 17 (53) | 15 (47) | 0.187 |
≥ 4 CM | 24 (83) | 5 (17) | 21 (72) | 8 (28) | 20 (71) | 8 (29) | |||
â—† Lymph Node Metastasis | |||||||||
Negative | 15 (75) | 5 (25) | 0.107 | 13 (65) | 7 (35) | 0.864 | 12 (63) | 7 (37) | 0.939 |
1 to 3 | 5 (42) | 7 (58) | 6 (50) | 6 (50) | 2 (29) | 5 (71) | |||
4 to 9 | 12 (67) | 6 (33) | 11 (61) | 7 (39) | 12 (67) | 6 (33) | |||
10 or more | 9 (90) | 1 (10) | 6 (60) | 4 (40) | 5 (56) | 4 (44) | |||
Histological Grade (SBR) | |||||||||
II | 14 (45) | 17 (56) | <0.001 | 12 (39) | 19 (61) | 0.002 | 12 (40) | 18 (60) | 0.001 |
III | 28 (90) | 3 (10) | 25 (81) | 6 (19) | 25 (83) | 5 (17) | |||
Lymphovascular Invasion | |||||||||
Positive | 26 (70) | 11 (30) | 0.782 | 25 (68) | 12 (32) | 0.187 | 23 (64) | 13 (36) | 0.787 |
Negative | 16 (64) | 9 (36) | 12 (48) | 13 (52) | 14 (58) | 10 (42) | |||
Her2/neu status | |||||||||
Positive | 13 (62) | 8 (38) | 0.588 | 18 (62) | 11 (38) | 0.798 | 17 (61) | 11 (39) | 1.000 |
Negative | 16 (64) | 22 (58) | 19 (58) | 14 (42) | 20 (63) | 12 (38) | |||
ER status | |||||||||
Positive | 24 (57) | 18 (43) | 0.010 | 21 (50) | 21 (50) | 0.029 | 19 (48) | 21 (53) | 0.001 |
Negative | 18 (90) | 2 (10) | 16 (80) | 4 (20) | 18 (90) | 2 (10) | |||
PR status | |||||||||
Positive | 17 (57) | 13 (43) | 0.103 | 15 (50) | 15 (50) | 0.195 | 11 (38) | 18 (62) | <0.001 |
Negative | 25 (78) | 7 (22) | 22 (69) | 10 (31) | 26 (84) | 5 (16) | |||
Neo-adjuvant Chemotherapy | |||||||||
With | 23 (64) | 13 (36) | 0.584 | 20 (56) | 16 (44) | 0.600 | 23 (66) | 12 (34) | 0.591 |
Without | 19 (73) | 7 (27) | 17 (65) | 9 (35) | 14 (56) | 11 (44) | |||
Lymphocyte Infiltration | |||||||||
Focal | 14 (52) | 13 (48) | 0.051 | 12 (44) | 15 (56) | 0.017 | 12 (46) | 14 (54) | 0.076 |
Moderate | 14 (74) | 5 (26) | 11 (58) | 8 (42) | 13 (68) | 6 (32) | |||
Severe | 14 (88) | 2 (13) | 14 (88) | 2 (13) | 12 (80) | 3 (20) | |||
B7-H1 expression of Tumor cells | |||||||||
Positive | 17 (89) | 2 (11) | 0.019 | 17 (89) | 2 (11) | 0.002 | 15 (83) | 3 (17) | 0.041 |
Negative | 25 (58) | 18 (42) | 20 (47) | 23 (53) | 22 (52) | 20 (48) | |||