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Table 2 Association between ERCC1 Asn118Asn, ASE-1G-21A, RAI IVS1 A4364G polymorphism and haplotype and risk of colorectal cancer

From: A haplotype of polymorphisms in ASE-1, RAI and ERCC1and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a danish prospective case-cohort study

   Men Women
  SNP N cases/sub-cohort IRRab CI (95%)c Pd N cases/sub-cohort IRRab CI (95%)c Pd
ERCC1 Asn118Asn TT 84/177 1e *   84/156 1e *  
  CT 100/193 1.04 0.72–1.50 0.66 66/156 0.78 0.51–1.19 0.48
  CC 34/61 1.13 0.66–1.94   27/52 0.90 0.50–1.63  
  missing 3/11     7/4    
ASE-1 G-21A GG 152/299 1e *   124/248 1e *  
  AG 60/124 0.94 0.64–1.38 0.73 45/106 0.85 0.55–1.32 0.96
  AA 7/10 2.11 0.71–6.21   9/11 1.58 0.60–4.18  
  missing 2/9     6/3    
RAI IVS1 A4364G AA 156/280 1e *   107/230 1e *  
  AG 56/138 0.69 0.47–1.03 0.13 61/124 1.17 0.77–1.80 0.20
  GG 6/13 0.89 0.31–2.57   8/10 1.95 0.71–5.33  
  missing 3/11        
High risk haplotype No 165/319 1e *   125/280 1e *  
  Yesf 53/110 1.01 0.68–1.51   51/82 1.35 0.84–2.16  
  missing 3/13     8/6    
  1. a) IRR: incidence rate ratio
  2. b) Adjusted for average smoking intensity, intake of alcohol, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy.
  3. c) CI: 95% confidence interval
  4. d) P: trend test
  5. e) The genotype serves as reference category
  6. f) Homozygous carriers of the haplotype compared to the rest. Homozygous carrier of the previously identified haplotype consisting of ERCC1 Asn118AsnTT, ASE-1 G-21AGG and RAI IVS1 A4364GAA