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Table 2 Association between ERCC1 Asn118Asn, ASE-1G-21A, RAI IVS1 A4364G polymorphism and haplotype and risk of colorectal cancer

From: A haplotype of polymorphisms in ASE-1, RAI and ERCC1and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a danish prospective case-cohort study

  

Men

Women

 

SNP

N cases/sub-cohort

IRRab

CI (95%)c

Pd

N cases/sub-cohort

IRRab

CI (95%)c

Pd

ERCC1 Asn118Asn

TT

84/177

1e

*

 

84/156

1e

*

 
 

CT

100/193

1.04

0.72–1.50

0.66

66/156

0.78

0.51–1.19

0.48

 

CC

34/61

1.13

0.66–1.94

 

27/52

0.90

0.50–1.63

 
 

missing

3/11

   

7/4

   

ASE-1 G-21A

GG

152/299

1e

*

 

124/248

1e

*

 
 

AG

60/124

0.94

0.64–1.38

0.73

45/106

0.85

0.55–1.32

0.96

 

AA

7/10

2.11

0.71–6.21

 

9/11

1.58

0.60–4.18

 
 

missing

2/9

   

6/3

   

RAI IVS1 A4364G

AA

156/280

1e

*

 

107/230

1e

*

 
 

AG

56/138

0.69

0.47–1.03

0.13

61/124

1.17

0.77–1.80

0.20

 

GG

6/13

0.89

0.31–2.57

 

8/10

1.95

0.71–5.33

 
 

missing

3/11

       

High risk haplotype

No

165/319

1e

*

 

125/280

1e

*

 
 

Yesf

53/110

1.01

0.68–1.51

 

51/82

1.35

0.84–2.16

 
 

missing

3/13

   

8/6

   
  1. a) IRR: incidence rate ratio
  2. b) Adjusted for average smoking intensity, intake of alcohol, fruits/vegetables, fish/poultry, red and processed meat, dietary fibres, BMI and hormone replacement therapy.
  3. c) CI: 95% confidence interval
  4. d) P: trend test
  5. e) The genotype serves as reference category
  6. f) Homozygous carriers of the haplotype compared to the rest. Homozygous carrier of the previously identified haplotype consisting of ERCC1 Asn118AsnTT, ASE-1 G-21AGG and RAI IVS1 A4364GAA