K-rasmutations in sinonasal cancers in relation to wood dust exposure

BMC Cancer

Table 6 Lists the histology, exposure data and mutations from sinonasal patients harbouring K-ras mutations.

Patient	Most recent job title according to the Central person registry	Histology	Interview	Smoking	Other potential confunders	Wood dust exposure according to interview	Mutation
15	-	High-grade Adenocarcinoma	No	NA	NA	No	GGT→GAT
64	Master joiner	Low-grade Adenocarcinoma	Yes	No	Formaldehyde	Yes	Ambiguous (codon 12 3^rd or codon 13, nt 1 or 2)
76	Master joiner	Intestinal-type Adenocarcinoma	Yes	Yes	Formaldehyde	Yes	Ambiguous (GGC→GAC)
86	Master joiner	Low-grade Adenocarcinoma	Yes	Yes	Formaldehyde	Yes	GGT→GAT
91	Farmer	Intestinal-type Adenocarcinoma	Yes	Yes	No	Yes	GGT→GAT
93	Long distance driver	Squamos cell carcinoma	Yes	Yes	No	No	GGT→GCT
160	Worker	Low-grade Adenocarcinoma	Yes	Yes	No	No	Ambiguous (codon 12, nt 1 or 2)
178	Associate professor	Low-grade Adenocarcinoma	Yes	No	No	No	GGT→GTT

NA = data not available, since no interview was completed. Wood dust exposure is based on information from interview. Where interview data was not available trade and job codes from the National Pension Fund (NPF) or self reported job titles in Central Person Registry (CPR) were used. A minimum employment length of one year was set as a lower limit. Patients without any records in NPF and CPR are also regarded as not exposed since they have not been an employee and therefore unlikely to be exposed to wood dust. The information from the interview was weighted more important than that in the data retrieved from the two registers.

ISSN: 1471-2407