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Table 5 Effect of zosuquidar to the cytotoxicity of DNR, Mitox and Mylotarg in 31 AML patient cells

From: Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

  Modulation* No modulation
Active P-gp (D > 0.3) 71% (5/7) 29% (2/7)
No active P-gp (D < 0.3) 13% (3/24) 87% (21/24)
  1. Modulation* means the enhanced cytotoxicity with zosuquidar.