Table 1 Modulation of cytotoxicity of K562, HL60 and their variant resistant cells

K562

None

0.28 ± 0.09

0.071 ± 0.026

0.60 ± 0.21

57.3 ± 6.5

Zosuquidar

0.26 ± 0.09

1.1

0.071 ± 0.042

1.0

0.095 ± 0.029

6.3

58.4 ± 10.1

1.0

CsA

0.23 ± 0.12

1.2

0.068 ± 0.039

1.0

0.14 ± 0.05

4.3

56.6 ± 4.2

1.0

K562/HHT40

None

2.3 ± 0.2

0.27 ± 0.06

1.7 ± 0.2

197.6 ± 44.4

Zosuquidar

0.66 ± 0.08

3.5

0.20 ± 0.07

1.4

0.33 ± 0.06

5.2

85.4 ± 2.9

2.3

CsA

0.51 ± 0.08

4.5

0.24 ± 0.11

1.1

0.45 ± 0.06

3.8

91.3 ± 9.3

2.2

K562/HHT90

None

3.6 ± 1.5

0.17 ± 0.11

1.9 ± 0.9

409.6 ± 70.2

Zosuquidar

0.37 ± 0.14

9.7

0.12 ± 0.09

1.4

0.13 ± 0.05

14.6

80.4 ± 8.3

5.8

CsA

0.32 ± 0.19

11.3

0.10 ± 0.06

1.7

0.25 ± 0.18

7.6

81.8 ± 8.3

5.0

K562/DOX

None

>50^b

1.82 ± 0.17

>50

>720

Zosuquidar

1.1 ± 0.4

>45.5

0.21 ± 0.03

8.7

0.53 ± 0.10

>94.3

88.8 ± 1.9

>8.1

CsA

10.5 ± 1.6

>4.8

0.30 ± 0.10

6.1

4.29 ± 0.22

>11.7

639.1 ± 70.1

>1.1

HL60

None

0.16 ± 0.03

0.053 ± 0.004

0.48 ± 0.22

40.5 ± 5.2

131.9 ± 72.3

Zosuquidar

0.13 ± 0.04

1.2

0.057 ± 0.008

0.9

0.09 ± 0.03

5.3

41.7 ± 3.1

1.0

83.8 ± 9.5

1.6

CsA

0.10 ± 0.02

1.6

0.033 ± 0.008

1.6

0.13 ± 0.07

3.7

33.6 ± 2.6

1.2

35.5 ± 1.0

3.7

HL60/ADR

None

2.1 ± 0.4

0.51 ± 0.03

1.5 ± 0.2

60.7 ± 12.4

>2000

Zosuquidar

2.4 ± 0.5

0.9

0.50 ± 0.03

1.0

1.4 ± 0.4

1.1

58.6 ± 4.6

1.0

>2000

ND

CsA

0.49 ± 0.04

4.3

0.30 ± 0.09

1.7

0.51 ± 0.03

2.9

48.7 ± 5.3

1.2

67.6 ± 7.6

>29.9

HL60/DNR

None

>40

0.51 ± 0.05

>20

489.9 ± 24.5

>2000

Zosuquidar

0.49 ± 0.16

>81.6

0.14 ± 0.01

3.6

0.22 ± 0.06

>90.1

46.5 ± 9.7

10.5

620.5 ± 38.9

3.2

CsA

2.5 ± 0.8

>16

0.15 ± 0.00

3.4

1.4 ± 0.6

>14.3

60.3 ± 5.0

8.1

>2000

ND