Resectable adenocarcinomas in the pancreatic head: the retroperitoneal resection margin is an independent prognostic factor

Table 1 Origin of tumour versus margin involvement and other histopathologic characteristics in 114 periampullary adenocarcinomas

	Origin of tumour				Total (n = 114)	p-value^a
	Ampulla (n = 41)	Duodenum (n = 16)	Distal bile duct (n = 17)	Pancreas (n = 40)
Margin involvement						0.009^b
Any margin (R1 resections)	10	2	10	18	40
Retroperitoneal	9	1	8	14	32
Pancreatic neck	2	1	5	7	15
Distal bile duct	0	0	0	2	2
No margin (R0 resections)	31	14	7	22	74
Other histopathologic characteristics
Nodal status						0.005
N1	17	10	7	31	65
N0	24	6	10	9	49
Degree of differentiation						0.009
Poor	8	5	9	21	43
High or moderate	33	11	8	19	71
Vessel involvement						0.013
yes	9	4	9	21	43
no	32	12	8	19	71
Perineural infiltration						<0.001
yes	13	6	11	32	62
no	28	10	6	8	52
Tumour size						<0.001^c
large (diameter ≥ 2.6 cm)	8	11	6	23	48
small (diameter ≤ 2.5 cm)	33	5	11	17	66

^aChi-square test, when not otherwise specified
^bR1 vs R0 resection
^cMeasured as a continuous variable, Kruskal-Wallis test and Mann-Whitney test (pancreatic vs non-pancreatic)

ISSN: 1471-2407