Table 4 Studies measuring circulating celecoxib levels
Population | Subjects | Weeks On Drug | Dose (mg)1 | Last Dose (hrs)2 | Source | Celecoxib concentration (ng/mL) |
|---|---|---|---|---|---|---|
Healthy Adults [18] | 8 | 2 | 200 b.i.d. | up to 25 | serum | 437 |
Healthy Adults [18] | 35 | 2 | 40 q.d. | 13 | plasma | 568 |
Healthy Adults [18] | 24 | 2 | 200 b.i.d. | up to 24 | plasma | 500 |
Healthy Adults [20] | 35 | 6 | 400 q.d. | 13 | plasma | 601 |
Elderly Adults [21] | 8 | 1 | 200 b.i.d. | 2 | plasma | 755 |
Pediatric cancer patients [22] | 9 | 250 mg/kg | b.i.d. | 6 | plasma | 668 |
Adult cancer patients [23] | 4 | week3 | 400 b.i.d. | 6–8 | plasma | 1087 |