Figure 1

Change in NAF PGE ₂ relative to plasma celecoxib level based on menopausal status and dose. (A) Premenopausal women who received 200 mg celecoxib bid. (B) Postmenopausal women who received 200 mg celecoxib bid.(C) Premenopausal women who received 400 mg celecoxib bid. (D) Postmenopausal women who received 400 mg celecoxib bid. The horizontal line in each graph represents no change in PGE₂ from pre- to posttreatment. Values above the horizontal line represent an increase in PGE₂ posttreatment, values below a decrease.