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Table 1 Activated protein levels in PDAC compared with histologically normal duct cells

From: Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis

Marker High IHC score PDAC (%) Duct (%) p-value
Cytoplasm     
p-JNK ≥ 2 77 4 <0.0001
p-ERK ≥ 2 62 8 <0.0001
p-SRC ≥ 2 73 40 0.0005
S727 p-STAT3 ≥ 3 38 4 0.005
T308 p-PKB ≥ 2 69 12 <0.0001
p-S6K ≥2 27 16 0.5
S473p-PKB ≥2 15 0 0.1
p-NFκB ≥2 19 4 0.2
p-S6 ≥2 54 40 0.4
p-p38 ≥ 2 65 20 0.002
Y705 p-STAT3 ≥ 2 85 26 0.0005
p-GSK3β ≥ 3 50 12 0.006
p-mTOR ≥ 3 19 0 0.05
p-RAF ≥ 3 62 24 0.01
p-βCAT ≥ 2 42 96 <0.0001
Nucleus     
p-NFκB ≥3 50 56 1
p-ERK ≥ 3 62 16 0.001
p-p38 ≥ 3 62 20 0.004
p-JNK ≥ 3 26 0 0.01
T308p-PKB ≥3 27 8 0.1
S727p-STAT3 ≥2 77 80 1
S473 p-PKB ≥ 2 62 16 0.001
Y705p-STAT3 ≥2 69 56 0.4
p-βCAT ≥2 35 32 1
p-GSK3β ≥1 23 20 1
  1. Proportions of PDAC and duct specimens are split into low and high groups of IHC scores. The results of Fisher's exact test are highlighted for significant differences (p ≤ 0.05) and trends (p = 0.06). Listed are percentages of specimens with high protein levels based on a total of 26 PDAC (T specimens) and 25 normal ducts (D and Dt specimens).