Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer

BMC Cancer

Table 2 Univariate analysis of factors regarding overall survival (OS) and recurrence-free survival (RFS)

Variable	Categorisation	Tumour-related death (OS)			Tumour recurrence (RFS)
		n	events	p^c	n	events	p^c
*Clinicopathological data:*
Tumour stage^a
	pT1	61	11	0.001	59	14	<0.0001
	pT2	96	34		93	43
	pT3	14	5		13	7
	pT4	28	17		26	18
Lymph node status^a
	pN0	89	15	<0.0001	87	17	<0.0001
	pN1-3	105	46		102	60
Histological grade
	G1	22	5	0.003	21	6	0.001
	G2	90	23		86	29
	G3	87	39		85	46
Multifocality
	unifocal tumour	174	55	0.165	168	70	0.348
	multifocal tumour	27	12		25	12
Histological type
	ductal	165	53	0.333	162	70	0.494
	lobular	15	8		13	6
	other	18	6		16	5
*Immunohistochemistry (IHC):*
Oestrogen receptor status
	negative	57	24	0.027	57	29	0.057
	positive	103	27		99	33
Progesterone receptor status
	negative	115	49	0.001	109	52	0.015
	positive	53	8		53	14
HER2 IHC
	weak (0–2+)	142	42	0.055	135	53	0.120
	strong (3+)	31	14		31	16
FOXM1^b
	negative (IRS 0–1)	56	14	0.110	54	23	0.581
	positive (IRS 2–12)	146	53		140	59

^aAccording to UICC: TNM Classification of Malignant Tumours. 6^th edn (2002) Sobin LH, Wittekind CH (eds) Wiley: New York
^bFOXM1 nuclear immunoreactivity: negative = IRS 0–1, positive = IRS 2–12
^cLog-rank test (two-sided), bold face representing significant data (P < 0.05)

ISSN: 1471-2407