Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer

BMC Cancer

Table 1 Clinicopathological and immunohistochemical parameters in relation to nuclear FOXM1 immunoreactivity

Variable	Categorisation	FOXM1 immunoreactivity
		n analysable	negative^b	positive^b	p^c
*Clinicopathological data:*
Tumour stage^a
	pT1	61	18	43	0.339
	pT2	96	27	69
	pT3	14	1	13
	pT4	28	9	19
Lymph node status^a
	pN0	55	28	61	0.425
	pN1-3	139	27	78
Histological grade
	G1	22	10	12	0.146
	G2	90	25	65
	G3	87	21	66
Multifocality
	unifocal tumour	174	48	126	0.820
	multifocal tumour	27	8	19
Histological type
	ductal	165	48	117	0.133
	lobular	15	1	14
	other	18	6	12
*Immunohistochemistry (IHC):*
Oestrogen receptor status
	negative	57	9	48	0.085
	positive	103	29	74
Progesterone receptor status
	negative	115	27	88	0.702
	positive	53	14	39
HER2 status
	weak (0–2+)	154	45	109	0.045
	strong (3+)	18	1	17

^aAccording to UICC: TNM Classification of Malignant Tumours. 6^th edn (2002) Sobin LH, Wittekind CH (eds) Wiley: New York
^bFOXM1 nuclear immunoreactivity: negative = IRS 0–1, positive = IRS 2–12
^cFisher's exact test (two-sided), bold face representing significant data (P < 0.05)

ISSN: 1471-2407