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Table 3 Personal, clinical and tumoral phenotypic characteristics comparison from both BC and MM pathologies in the four SNPs tested

From: Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

Tumour

 

rs4516035

 

rs2228570

 

rs731236

 

rs739837

 

Type

Characteristic

OR* (95% CI)

p-value

OR* (95% CI)

p-value

OR* (95% CI)

p-value

OR* (95% CI)

p-value

BREAST CANCER

 

Metastasis‡

0.53 (0.25–1.11)

0.09

1.00 (0.51–1.96)

0.99

1.20 (0.63–2.27)

0.58

1.11 (0.57–2.17)

0.75

 

Tumor histology (Invasive)‡

0.87 (0.57–1.32)

0.51

0.83 (0.54–1.28)

0.40

1.10 (0.72–1.69)

0.66

0.75 (0.49–1.15)

0.19

 

Tumor grade (Grade > 1)‡

0.93 (0.67–1.30)

0.68

1.19 (0.84–1.68)

0.33

1.22 (0.87–1.70)

0.26

0.76 (0.54–1.05)

0.09

 

Tumor size (> 2 cm)‡

1.02 (0.77–1.35)

0.92

0.98 (0.73–1.30)

0.88

1.14 (0.86–1.51)

0.37

0.81 (0.61–1.08)

0.15

 

Nodal involvement‡

0.93 (0.70–1.23)

0.61

0.95 (0.71–1.27)

0.72

0.94 (0.71–1.25)

0.69

1.09 (0.82–1.45)

0.54

 

ER positive‡

0.96 (0.66–1.41)

0.85

1.24 (0.84–1.84)

0.28

1.31 (0.90–1.90)

0.16

1.02 (0.71–1.46)

0.91

 

PR positive‡

0.92 (0.67–1.26)

0.60

1.12 (0.80–1.55)

0.51

0.91 (0.67–1.24)

0.56

1.12 (0.83–1.51)

0.48

MELANOMA

 

Light Eye Colour+

1.03 (0.79–1.34)

0.82

0.91 (0.69–1.21)

0.52

0.92 (0.70–1.21)

0.56

1.06 (0.81–1.39)

0.64

 

Blond/Red Hair Colour+

0.99 (0.71–1.40)

0.99

0.78 (0.55–1.13)

0.19

1.02 (0.73–1.44)

0.89

1.45 (0.89–1.74)

0.20

 

Fair Skin Colour+

0.97 (0.75–1.26)

0.83

1.08 (0.82–1.42)

0.57

0.86 (0.66–1.12)

0.25

1.31 (1.00–1.70)

0.048

 

N° of Nevi = 50+

0.97 (0.66–1.40)

0.85

1.00 (0.67–1.49)

0.99

1.06 (0.72–1.54)

0.77

1.34 (0.90–1.97)

0.15

 

Presence of Lentigines+

1.03 (0.79–1.34)

0.84

0.79 (0.59–1.05)

0.11

1.20 (0.91–1.58)

0.21

0.90 (0.69–1.18)

0.45

 

Presence of Childhood Sunburns+

1.12 (0.87–1.45)

0.39

0.65 (0.49–0.86)

0.003

1.10 (0.84–1.43)

0.49

0.91 (0.70–1.19)

0.50

 

Other MM‡

1.26 (0.52–3.03)

0.61

2.43 (0.95–6.19)

0.060

1.83 (0.73–4.56)

0.19

0.70 (0.26–1.85)

0.47

 

Fitzpatrick's photoype I/II‡

0.74 (0.51–1.09)

0.13

0.85 (0.63–1.46)

0.89

0.91 (0.62–1.34)

0.63

1.43 (0.97–2.12)

0.070

 

Tumor Location (Head/Neck/Trunk)‡

1.54 (1.08–2.20)

0.020

1.16 (0.79–1.72)

0.45

1.16 (0.81–1.65)

0.42

1.17 (0.82–1.67)

0.38

 

Breslow Index (T2/T3/T4)‡

1.04 (0.72–1.51)

0.82

1.20 (0.80–1.79)

0.38

0.84 (0.57–1.24)

0.38

1.01 (0.69–1.47)

0.96

  1. *OR: Odds Ratio per minor allele; CI: Confidence Interval, unadjusted p-values.
  2. +Cases and controls pooled for each variable.
  3. ‡Cases only considered.
  4. Statistically significant results (p < 0.05) indicated in bold.