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Table 3 Personal, clinical and tumoral phenotypic characteristics comparison from both BC and MM pathologies in the four SNPs tested

From: Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

Tumour   rs4516035   rs2228570   rs731236   rs739837  
Type Characteristic OR* (95% CI) p-value OR* (95% CI) p-value OR* (95% CI) p-value OR* (95% CI) p-value
BREAST CANCER
  Metastasis 0.53 (0.25–1.11) 0.09 1.00 (0.51–1.96) 0.99 1.20 (0.63–2.27) 0.58 1.11 (0.57–2.17) 0.75
  Tumor histology (Invasive) 0.87 (0.57–1.32) 0.51 0.83 (0.54–1.28) 0.40 1.10 (0.72–1.69) 0.66 0.75 (0.49–1.15) 0.19
  Tumor grade (Grade > 1) 0.93 (0.67–1.30) 0.68 1.19 (0.84–1.68) 0.33 1.22 (0.87–1.70) 0.26 0.76 (0.54–1.05) 0.09
  Tumor size (> 2 cm) 1.02 (0.77–1.35) 0.92 0.98 (0.73–1.30) 0.88 1.14 (0.86–1.51) 0.37 0.81 (0.61–1.08) 0.15
  Nodal involvement 0.93 (0.70–1.23) 0.61 0.95 (0.71–1.27) 0.72 0.94 (0.71–1.25) 0.69 1.09 (0.82–1.45) 0.54
  ER positive 0.96 (0.66–1.41) 0.85 1.24 (0.84–1.84) 0.28 1.31 (0.90–1.90) 0.16 1.02 (0.71–1.46) 0.91
  PR positive 0.92 (0.67–1.26) 0.60 1.12 (0.80–1.55) 0.51 0.91 (0.67–1.24) 0.56 1.12 (0.83–1.51) 0.48
MELANOMA
  Light Eye Colour+ 1.03 (0.79–1.34) 0.82 0.91 (0.69–1.21) 0.52 0.92 (0.70–1.21) 0.56 1.06 (0.81–1.39) 0.64
  Blond/Red Hair Colour+ 0.99 (0.71–1.40) 0.99 0.78 (0.55–1.13) 0.19 1.02 (0.73–1.44) 0.89 1.45 (0.89–1.74) 0.20
  Fair Skin Colour+ 0.97 (0.75–1.26) 0.83 1.08 (0.82–1.42) 0.57 0.86 (0.66–1.12) 0.25 1.31 (1.00–1.70) 0.048
  N° of Nevi = 50+ 0.97 (0.66–1.40) 0.85 1.00 (0.67–1.49) 0.99 1.06 (0.72–1.54) 0.77 1.34 (0.90–1.97) 0.15
  Presence of Lentigines+ 1.03 (0.79–1.34) 0.84 0.79 (0.59–1.05) 0.11 1.20 (0.91–1.58) 0.21 0.90 (0.69–1.18) 0.45
  Presence of Childhood Sunburns+ 1.12 (0.87–1.45) 0.39 0.65 (0.49–0.86) 0.003 1.10 (0.84–1.43) 0.49 0.91 (0.70–1.19) 0.50
  Other MM 1.26 (0.52–3.03) 0.61 2.43 (0.95–6.19) 0.060 1.83 (0.73–4.56) 0.19 0.70 (0.26–1.85) 0.47
  Fitzpatrick's photoype I/II 0.74 (0.51–1.09) 0.13 0.85 (0.63–1.46) 0.89 0.91 (0.62–1.34) 0.63 1.43 (0.97–2.12) 0.070
  Tumor Location (Head/Neck/Trunk) 1.54 (1.08–2.20) 0.020 1.16 (0.79–1.72) 0.45 1.16 (0.81–1.65) 0.42 1.17 (0.82–1.67) 0.38
  Breslow Index (T2/T3/T4) 1.04 (0.72–1.51) 0.82 1.20 (0.80–1.79) 0.38 0.84 (0.57–1.24) 0.38 1.01 (0.69–1.47) 0.96
  1. *OR: Odds Ratio per minor allele; CI: Confidence Interval, unadjusted p-values.
  2. +Cases and controls pooled for each variable.
  3. Cases only considered.
  4. Statistically significant results (p < 0.05) indicated in bold.