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Table 2 Genotype frequencies comparison between cases and controls in the four SNPs tested, in both BC and MM pathologies

From: Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

    BREAST CANCER MELANOMA
  Statistical Genotype non-adjusted adjusted non-adjusted adjusted
SNP ID model alleles OR* (95% CI) p-value OR* (95% CI) p-value OR* (95% CI) p-value OR* (95% CI) p-value
rs4516035 Codominant CT 1.20 (0.92–1.56) 0.19 1.15 (0.83–1.58) 0.40 1.08 (0.73–1.60) 0.69 1.17 (0.70–1.96) 0.54
   CC 1.16 (0.82–1.65) 0.41 0.97 (0.63–1.49) 0.88 1.51 (0.90–2.53) 0.12 1.79 (0.91–3.53) 0.09
  Per minor allele C- 1.09 (0.92–1.29) 0.30 1.01 (0.82–1.25) 0.91 1.20 (0.94–1.55) 0.15 1.31 (0.94–1.81) 0.11
rs2228570 Codominant GA 1.14 (0.88–1.47) 0.32 1.26 (0.89–1.66) 0.22 1.09 (0.75–1.57) 0.66 1.23 (0.76–2.01) 0.40
   AA 1.41 (0.96–2.08) 0.08 1.65 (1.02–2.65) 0.041 0.69 (0.38–1.25) 0.22 1.23 (0.55–2.73) 0.61
  Per minor allele A- 1.17 (0.98–1.40) 0.08 1.26 (1.02–1.57) 0.036 0.91 (0.70–1.19) 0.49 1.15 (0.81–1.64) 0.43
rs731236 Codominant CT 0.84 (0.64–1.09) 0.19 0.82 (0.59–1.13) 0.22 1.26 (0.85–1.87) 0.25 1.06 (0.63–1.78) 0.81
   CC 0.70 (0.50–0.98) 0.040 0.72 (0.48–1.09) 0.13 1.09 (0.64–1.84) 0.76 1.17 (0.57–2.39) 0.66
  Per minor allele C- 0.84 (0.71–0.99) 0.034 0.85 (0.69–1.03) 0.10 1.08 (0.84–1.40) 0.55 1.08 (0.77–1.52) 0.66
rs739837 Codominant TG 0.96 (0.72–1.27) 0.76 0.96 (0.69–1.35) 0.83 0.89 (0.59–1.36) 0.60 0.64 (0.36–1.13) 0.12
   GG 1.03 (0.74–1.44) 0.86 1.30 (0.87–1.96) 0.20 0.82 (0.50–1.36) 0.45 0.69 (0.35–1.38) 0.29
  Per minor allele G- 1.01 (0.86–1.20) 0.87 1.13 (0.92–1.38) 0.25 0.91 (0.71–1.17) 0.45 0.83 (0.59–1.16) 0.28
  1. *OR: Odds Ratio estimated under codominant and log-additive models; CI: Confidence Interval.
  2. Adjusted for age at diagnosis, number of live births, age at menarche and menopause status.
  3. Adjusted for eye colour, hair colour, skin colour, number of nevi, lentigines, and childhood sunburn.
  4. Statistically significant results (p < 0.05) indicated in bold.