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Table 2 Genotype frequencies comparison between cases and controls in the four SNPs tested, in both BC and MM pathologies

From: Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

   

BREAST CANCER

MELANOMA

 

Statistical

Genotype

non-adjusted

adjusted†

non-adjusted

adjusted‡

SNP ID

model

alleles

OR* (95% CI)

p-value

OR* (95% CI)

p-value

OR* (95% CI)

p-value

OR* (95% CI)

p-value

rs4516035

Codominant

CT

1.20 (0.92–1.56)

0.19

1.15 (0.83–1.58)

0.40

1.08 (0.73–1.60)

0.69

1.17 (0.70–1.96)

0.54

  

CC

1.16 (0.82–1.65)

0.41

0.97 (0.63–1.49)

0.88

1.51 (0.90–2.53)

0.12

1.79 (0.91–3.53)

0.09

 

Per minor allele

C-

1.09 (0.92–1.29)

0.30

1.01 (0.82–1.25)

0.91

1.20 (0.94–1.55)

0.15

1.31 (0.94–1.81)

0.11

rs2228570

Codominant

GA

1.14 (0.88–1.47)

0.32

1.26 (0.89–1.66)

0.22

1.09 (0.75–1.57)

0.66

1.23 (0.76–2.01)

0.40

  

AA

1.41 (0.96–2.08)

0.08

1.65 (1.02–2.65)

0.041

0.69 (0.38–1.25)

0.22

1.23 (0.55–2.73)

0.61

 

Per minor allele

A-

1.17 (0.98–1.40)

0.08

1.26 (1.02–1.57)

0.036

0.91 (0.70–1.19)

0.49

1.15 (0.81–1.64)

0.43

rs731236

Codominant

CT

0.84 (0.64–1.09)

0.19

0.82 (0.59–1.13)

0.22

1.26 (0.85–1.87)

0.25

1.06 (0.63–1.78)

0.81

  

CC

0.70 (0.50–0.98)

0.040

0.72 (0.48–1.09)

0.13

1.09 (0.64–1.84)

0.76

1.17 (0.57–2.39)

0.66

 

Per minor allele

C-

0.84 (0.71–0.99)

0.034

0.85 (0.69–1.03)

0.10

1.08 (0.84–1.40)

0.55

1.08 (0.77–1.52)

0.66

rs739837

Codominant

TG

0.96 (0.72–1.27)

0.76

0.96 (0.69–1.35)

0.83

0.89 (0.59–1.36)

0.60

0.64 (0.36–1.13)

0.12

  

GG

1.03 (0.74–1.44)

0.86

1.30 (0.87–1.96)

0.20

0.82 (0.50–1.36)

0.45

0.69 (0.35–1.38)

0.29

 

Per minor allele

G-

1.01 (0.86–1.20)

0.87

1.13 (0.92–1.38)

0.25

0.91 (0.71–1.17)

0.45

0.83 (0.59–1.16)

0.28

  1. *OR: Odds Ratio estimated under codominant and log-additive models; CI: Confidence Interval.
  2. †Adjusted for age at diagnosis, number of live births, age at menarche and menopause status.
  3. ‡Adjusted for eye colour, hair colour, skin colour, number of nevi, lentigines, and childhood sunburn.
  4. Statistically significant results (p < 0.05) indicated in bold.