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Table 4 Univariate and multivariate analyses of prognosis using pathological factors and biomarkers of primary breast cancer

From: Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer

 

Disease-free survival

Variable

Univariate

Multivariate

 

HR

95% CI

p-value

HR

95% CI

p-value

Tumor size (≧2 cm vs <2 cm)

6.7

2.68–16.72

<0.0001

4.49

1.56–12.74

0.0047

Nodal status (+ vs -)

4.79

2.73–8.38

<0.0001

4.1

2.18–7.74

<0.0001

Nuclear grade (Grade 3 vs 1–2)

3.96

2.32–6.76

<0.0001

1.69

0.92–3.13

0.094

CENP-F (positive vs negative)

3.92

2.19–7.03

<0.0001

2.94

1.51–5.72

0.0015

p53 (positive vs negative)

2.35

1.36–4.09

0.0024

1.38

0.75–2.52

0.3

Ki67 (10% ≦ vs 10% >)

2.25

1.36–3.72

0.0016

2.05

1.18–3.56

0.011

HER2 (3+,FISH+ vs 0,1+,2+(FISH-))

2.11

1.07–4.16

0.031

1.79

0.84–3.8

0.13

ER (positive vs negative)

1.54

0.94–2.52

0.087

 

n/a

 
 

Overall survival

 

Univariate

Multivariate

Variable

HR

95% CI

p-value

HR

95% CI

p-value

Nodal status (+ vs -)

9.83

2.58–15.71

0.0041

11.88

1.45–97.09

0.021

Nuclear grade (Grade 3 vs 1–2)

3.73

1.25–11.15

0.0019

2.51

0.72–8.04

0.15

CENP-F (positive vs negative)

3.35

1.05–10.72

0.042

2.05

0.52–8.09

0.31

Tumor size (≧2 cm vs <2 cm)

2.28

1.3–3.99

0.0039

1.37

0.72–2.64

0.34

HER2 (3+,FISH+ vs 0,1+,2+(FISH-))

3.02

0.84–10.85

0.09

 

n/a

 

Ki67 (10% ≦ vs 10% >)

2.22

0.78–6.36

0.13

 

n/a

 

p53 (positive vs negative)

1.71

0.48–6.13

0.41

 

n/a

 

ER (positive vs negative)

1.26

0.44–3.62

0.67

 

n/a

 
  1. Abbreviations; HR, hazard ratio; CI, confidence interval; vs, versus; n/a, not applicable; positive, strong staining (2+) in 10% of cancer cells;negative, others
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BMC Cancer

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