Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin

BMC Cancer

Table 2 VE concentration, ROS activity, SOD activity, GSH activity and MDA content in mice serum from different groups (mean ± sd, n = 12)

Group	Vitamin E (μg/ml)	ROS (U/ml)	SOD (U/ml)	MDA (mmol/ml)	GSH-Px (U/ml)
Control	6.05 ± 1.81	1002.66 ± 112.72	164.79 ± 32.49	9.84 ± 1.16	746.03 ± 10.19
C+VE	14.23 ± 2.88^b	511.23 ± 85.45	200.87 ± 30.22	9.22 ± 1.24	800.94 ± 12.55
C+Q	5.01 ± 0.82	811.04 ± 43.54	152.27 ± 26.45	10.28 ± 1.12	752.16 ± 11.68
TS	3.82 ± 2.55^a	1238.71 ± 33.63^c	131.93 ± 29.49^e	10.54 ± 1.20	679.66 ± 6.25^f
TS+Q	7.11 ± 1.74	1155.87 ± 111.85^d	157.11 ± 16.96	9.95 ± 1.59	689.33 ± 4.32^f
TS+ VE	12.08 ± 0.88^b	577.88 ± 92.47	213.01 ± 25.35	9.97 ± 1.13	677.36 ± 4.50^f
TS+VE+Q	12.02 ± 1.33^b	748.43 ± 43.36	226.05 ± 33.14	9.76 ± 0.96	667.56 ± 8.10

^aVE was significant lower than that in other groups (p < 0.05); ^b VE in VE treated groups was significantly higher than those in other control groups (p < 0.05). ^cROS activity was significantly higher than that in control groups and VE treated groups; ^dROS activity was significantly higher than that in C+Q, C+VE, TS+VE and TS+VE+Q groups. ^eThe level of SOD activity was significantly lower than that in VE treated groups. No statistical significance was observed on MDA content in different groups.^fGSH-Px activities were significantly lower than those in control groups.

ISSN: 1471-2407