Table 2 Statistical analysis of allele and genotype distributions of IL1A, MCP-1, RANTES and TNF-A polymorphisms.
From: Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
Genotype frequencies | Control n = 311 | Case n = 298 | Genotype results | p value | OR | 95% confidence interval | Interaction análysis | ||
|---|---|---|---|---|---|---|---|---|---|
n | % | n | % | ||||||
Il-1 CC | 152 | 50.2 | 133 | 44.9 | Il-1 CT/TT versus CC [25] | 0.200 | 1.23 | 0.89 – 1.82 | |
Il-1 CT/TT | 151 | 49.8 | 163 | 55.1 | |||||
TNF-alpha GG | 256 | 82.6 | 221 | 74.7 | TNF-alpha AG/AA versus GG [13] | 0.017 | 1.61 | 1.09 – 2.64 | |
TNF-alpha AG/AA | 54 | 17.4 | 75 | 25.3 | |||||
MCP-1 AA | 178 | 57.2 | 174 | 58.4 | MCP-1 AG/GG versus AA [27] | 0.770 | 0.95 | 0.66 – 1.33 | |
MCP-1 AG/GG | 133 | 42.8 | 124 | 41.6 | |||||
RANTES GG | 221 | 72.5 | 192 | 64.6 | RANTES AG/AA versus GG [16] | 0.039 | 1.44 | 1.09 – 2.38 | |
RANTES AG/AA | 84 | 27.5 | 105 | 35.4 | |||||
TNF-alpha AG/AA and RANTES AG/AA | 0.012 | 2.45 | 1.22 – 4.94 | 0.416 | |||||
Allele frequencies | Allele results | ||||||||
Il-1 C | 426 | 70.3 | 401 | 67.5 | Il-1 C versus Il-1 T | 0.297 | 1.14 | 0.89–1.46 | |
Il-1 T | 180 | 29.7 | 193 | 32.5 | |||||
TNF-alpha G | 564 | 90.97 | 512 | 86.5 | TNF-alpha G versus A | 0.013 | 1.57 | 1.10–2.26 | |
TNF-alpha A | 56 | 9.03 | 80 | 13.5 | |||||
MCP-1 A | 479 | 77.01 | 448 | 75.2 | MCP-1 A versus G | 0.451 | 1.11 | 0.85–1.44 | |
MCP-1 G | 143 | 22.99 | 148 | 24.8 | |||||
RANTES G | 522 | 85.57 | 478 | 80.5 | RANTES G versus A | 0.018 | 1.44 | 1.03–1.95 | |
RANTES A | 88 | 14.43 | 116 | 19.5 | |||||