Figure 1
From: Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
HDAC 1 expression in normal and malignant renal tissue. In benign renal tissue HDAC 1 is focally expressed in nuclei of mesangial cells of the glomeruli and also tubular epithelia with a stronger expression in the distal part of the nephron (A). Clear cell RCC negative for HDAC 1, contrasting to the relatively strong staining in adjacent stroma (B). RCC displaying a strong and homogenous nuclear positivity in tumour cells (C). Papillary (D1) and chromophobe (D2) RCC with strong HDAC 1 expression.